Effects of fat and carbohydrate meals on colonic motor response

S. S.C. Rao, R. Kavelock, J. Beaty, K. Ackerson, P. Stumbo

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background-Ingestion of a meal stimulates colonic motility. It is unclear whether the nutrient composition of a meal affects colonic motor response. Aims-To investigate and compare the effects of a predominantly fat or carbohydrate meal on colonic motility. Methods-In 18 healthy subjects, ambulatory colonic manometry was performed by placing a six sensor, solid state probe from the mid-transverse colon to the rectum. In a randomised, crossover design, 10 and 27 hours after probe placement, subjects received 4.18 MJ meals containing 60% calories from fat or carbohydrate sources. Preprandial and postprandial pressure activity and motor patterns were evaluated. Results-Both meals induced phasic activity with a greater area under the curve (p<0.03) in the first postprandial hour, compared with the control period. Fat induced motor activity persisted longer (p<0.05) than that of the carbohydrate meal, but the onset of motor response was slower (p<0.001). Although both meals induced more (p<0.001) propagating pressure waves, only the fat meal induced more (p<0.05) simultaneous and retrograde waves. After both meals, 50% of subjects exhibited high amplitude (more than 103 mm Hg), prolonged duration (more than 13 seconds) propagating waves. Both meals induced greater activity (p<0.05) in the transverse/descending colon than in the rectosigmoid colon. Conclusions-Carbohydrate meals induce colonic motor response, but the effects are short lived when compared with fat meals. The prolonged, segmental, and retrograde phasic activity induced by the fat meal may delay colon transit. Thus meal composition influences colonic motor response.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalGut
Volume46
Issue number2
DOIs
StatePublished - May 30 2000

Fingerprint

Meals
Fats
Carbohydrates
Transverse Colon
Colon
Motor Activity
Descending Colon
Pressure
Manometry
Rectum
Cross-Over Studies
Area Under Curve
Healthy Volunteers
Eating
Food

Keywords

  • Carbohydrate
  • Colon motility
  • Fat
  • Gastrocolonic response
  • Meals

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Rao, S. S. C., Kavelock, R., Beaty, J., Ackerson, K., & Stumbo, P. (2000). Effects of fat and carbohydrate meals on colonic motor response. Gut, 46(2), 205-211. https://doi.org/10.1136/gut.46.2.205

Effects of fat and carbohydrate meals on colonic motor response. / Rao, S. S.C.; Kavelock, R.; Beaty, J.; Ackerson, K.; Stumbo, P.

In: Gut, Vol. 46, No. 2, 30.05.2000, p. 205-211.

Research output: Contribution to journalArticle

Rao, SSC, Kavelock, R, Beaty, J, Ackerson, K & Stumbo, P 2000, 'Effects of fat and carbohydrate meals on colonic motor response', Gut, vol. 46, no. 2, pp. 205-211. https://doi.org/10.1136/gut.46.2.205
Rao SSC, Kavelock R, Beaty J, Ackerson K, Stumbo P. Effects of fat and carbohydrate meals on colonic motor response. Gut. 2000 May 30;46(2):205-211. https://doi.org/10.1136/gut.46.2.205
Rao, S. S.C. ; Kavelock, R. ; Beaty, J. ; Ackerson, K. ; Stumbo, P. / Effects of fat and carbohydrate meals on colonic motor response. In: Gut. 2000 ; Vol. 46, No. 2. pp. 205-211.
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