Effects of fibrinogen in vivo on dentine permeability in the dog

D. H. Pashley, S. E. Galloway, F. Stewart

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Dentine permeability measurements were made each hour for 6 h in tooth cavities prepared in control dogs or dogs which had been pretreated with a purified fraction of snake venom to deplete their plasma of fibrinogen. The control dogs exhibited a progressive fall in dentine permeability (~ 50 per cent reduction in 6 h); the permeability in the fibrinogen-depleted dogs only fell 15 per cent in 6 h. The results implicate plasma proteins, particularly high molecular-weight proteins such as fibrinogen, as agents which reduce dentine permeability in vivo.

Original languageEnglish (US)
Pages (from-to)725-728
Number of pages4
JournalArchives of Oral Biology
Issue number9
StatePublished - 1984

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology


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