Effects of gender and age on esophageal biomechanical properties and sensation

Satish Sanku Chander Rao, Ranjit S. Mudipalli, Victor R. Mujica, Rig S. Patel, Bridget Zimmerman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

OBJECTIVES: The effects of gender and age on human esophageal function is poorly defined. Our aim was to investigate the sensory perception and the biomechanical properties of the esophagus both at the smooth muscle and the striated muscle segments in age- and gender-matched healthy subjects. Eleven older individuals (five men and six women, aged 55-82 yr) and 11 younger healthy individuals (five male and six female, aged 22-45 yr) participated in this study. METHODS: Graded balloon distentions were performed at the striated muscle and the smooth muscle segments of the esophagus in a random order using impedance planimetry. Impedance planimetry facilitated simultaneous assessments of the biomechanical properties and sensory perception. RESULTS: We found that both at the striated and smooth muscle segments, the cross-sectional area, circumferential wall tension-strain relationship and the sensory thresholds were similar between men and women. In contrast, at both of these segments, the cross-sectional area was larger (p < 0.05), the circumferential wall tension-strain association had shifted significantly (p < 0.05) to the left (i.e., the wall was stiffer), and the median thresholds for discomfort and pain were higher (p < 0.05) in older subjects. The biomechanical properties and thresholds for sensory perception also varied between the two esophageal segments. CONCLUSION: Aging was associated with a larger lumen and a stiffer but less sensitive esophageal wall. Thus, aging but not gender may influence esophageal function.

Original languageEnglish (US)
Pages (from-to)1688-1695
Number of pages8
JournalAmerican Journal of Gastroenterology
Volume98
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

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Striated Muscle
Sensory Thresholds
Smooth Muscle
Electric Impedance
Esophagus
Pain Threshold
Healthy Volunteers

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Effects of gender and age on esophageal biomechanical properties and sensation. / Rao, Satish Sanku Chander; Mudipalli, Ranjit S.; Mujica, Victor R.; Patel, Rig S.; Zimmerman, Bridget.

In: American Journal of Gastroenterology, Vol. 98, No. 8, 01.08.2003, p. 1688-1695.

Research output: Contribution to journalArticle

Rao, Satish Sanku Chander ; Mudipalli, Ranjit S. ; Mujica, Victor R. ; Patel, Rig S. ; Zimmerman, Bridget. / Effects of gender and age on esophageal biomechanical properties and sensation. In: American Journal of Gastroenterology. 2003 ; Vol. 98, No. 8. pp. 1688-1695.
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