Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

Tiago Tomazini Gonçalves, Carolina M. Lazaro, Fernanda G. De Mateo, Marcela C.B. Campos, Jackeline G.B. Mezencio, Mario A. Claudino, Patrícia de O. Carvalho, R Clinton Webb, Fernanda Priviero

Research output: Contribution to journalArticle

Abstract

Objective: The aim of the study was to evaluate the effects of supplementation with glucosyl hesperidin (GH), with or without physical training, on body weight, fat depot, glucose and plasma lipids, oxidative status and vascular function of rats fed with high-fat diet (HFD). Methods: After weaning, male Wistar rats were fed with an HFD plus fructose for 12 weeks and started receiving oral antioxidant supplementation and/or physical training after the fourth week of diet for eight further weeks. Body weight, epididymal and retroperitoneal fat, plasma glucose and lipids, oxidative status and mesenteric artery reactivity were evaluated. Results: Rats fed with HFD presented higher body weight gain and fat accumulation compared to control rats, while GH supplementation did not influence these parameters. Physical training reduced the body weight gain and fat accumulation and modulated the oxidative status by increasing superoxide dismutase activity and total antioxidant capacity and reducing lipid peroxidation. GH alone decreased lipid peroxidation. However, when given to exercised rats, it impaired the response elicited by physical training. HFD caused endothelial dysfunction, and neither GH nor physical exercise prevented it. Potency of sodium nitroprusside was increased in exercised animals but not in GH-supplemented rats. Conclusion: Physical exercise partially decreased the body fat accumulation, decreased plasma levels of glucose and lipids and improved general oxidative status and endothelium-independent relaxation in mesenteric arteries of rats fed with HFD. GH exhibited benefits only in the oxidative status. However, GH given in association with physical exercise did not cause further changes in addition to those promoted by physical exercise. On the contrary, in exercised animals, GH prevented those changes elicited by physical training in plasma glucose and lipids, oxidative status and endothelium-independent relaxation.

Original languageEnglish (US)
Pages (from-to)321-332
Number of pages12
JournalDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Volume11
DOIs
StatePublished - Jan 1 2018

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High Fat Diet
Blood Vessels
Body Weight
Lipids
Exercise
Adipose Tissue
Glucose
Mesenteric Arteries
Lipid Peroxidation
Weight Gain
Endothelium
Antioxidants
Intra-Abdominal Fat
glucosyl hesperidin
Nitroprusside
Weaning
Fructose
Superoxide Dismutase
Wistar Rats
Fats

Keywords

  • Antioxidants
  • Flavonoids
  • High-fat diet
  • Obesity
  • Oxidative stress
  • Physical activity
  • Physical exercise
  • Reactive oxygen species
  • Supplementation

ASJC Scopus subject areas

  • Internal Medicine
  • Pharmacology

Cite this

Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet. / Tomazini Gonçalves, Tiago; Lazaro, Carolina M.; De Mateo, Fernanda G.; Campos, Marcela C.B.; Mezencio, Jackeline G.B.; Claudino, Mario A.; Carvalho, Patrícia de O.; Webb, R Clinton; Priviero, Fernanda.

In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol. 11, 01.01.2018, p. 321-332.

Research output: Contribution to journalArticle

Tomazini Gonçalves, Tiago ; Lazaro, Carolina M. ; De Mateo, Fernanda G. ; Campos, Marcela C.B. ; Mezencio, Jackeline G.B. ; Claudino, Mario A. ; Carvalho, Patrícia de O. ; Webb, R Clinton ; Priviero, Fernanda. / Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet. In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2018 ; Vol. 11. pp. 321-332.
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T1 - Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

AU - Tomazini Gonçalves, Tiago

AU - Lazaro, Carolina M.

AU - De Mateo, Fernanda G.

AU - Campos, Marcela C.B.

AU - Mezencio, Jackeline G.B.

AU - Claudino, Mario A.

AU - Carvalho, Patrícia de O.

AU - Webb, R Clinton

AU - Priviero, Fernanda

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