Effects of hypoxia on vertebrate blood vessels

Michael James Russell, Ryan A. Dombkowski, Kenneth R. Olson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Hypoxia contracts mammalian respiratory vessels and increases vascular resistance in respiratory tissues of many vertebrates. In systemic vessels these responses vary, hypoxia relaxes mammalian vessels and contracts systemic arteries from cyclostomes. It has been proposed that hypoxic vasoconstriction in cyclostome systemic arteries is the antecedent to mammalian hypoxic pulmonary vasoconstriction, however, phylogenetic characterization of hypoxic responses is lacking. In this study, we characterized the hypoxic response of isolated systemic and respiratory vessels from a variety of vertebrates using standard myography. Pre-gill/respiratory (ventral aorta, afferent branchial artery, pulmonary artery) and post-gill/systemic (dorsal and thoracic aortas, efferent branchial artery) from lamprey (Petromyzon marinus), sandbar shark (Carcharhinus plumbeus), yellowfin tuna (Thunnus albacares), American bullfrog (Rana catesbeiana), American alligator (Alligator mississippiensis), Pekin duck (Anas platyrhynchos domesticus), chicken (Gallus domesticus) and rat (Rattus norvegicus) were exposed to hypoxia at rest or during pre-stimulation (elevated extracellular potassium, epinephrine or norepinephrine). Hypoxia produced a relaxation or transient contraction followed by relaxation in all pre-gill vessels, except for contraction in lamprey, and vasoconstriction or tri-phasic constriction-dilation-constriction in all pulmonary vessels. Hypoxia contracted systemic vessels from all animals except shark and rat and in pre-contracted rat aortas it produced a transient contraction followed by relaxation. These results show that while the classic "systemic hypoxic vasodilation and pulmonary hypoxic vasoconstriction" may occur in the microcirculation, the hypoxic response of the vertebrate macrocirculation is quite variable. These findings also suggest that hypoxic vasoconstriction is a phylogenetically ancient response.

Original languageEnglish (US)
Pages (from-to)55-63
Number of pages9
JournalJournal of Experimental Zoology Part A: Ecological Genetics and Physiology
Volume309
Issue number2
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

Fingerprint

vasoconstriction
hypoxia
Vasoconstriction
blood vessels
Blood Vessels
Vertebrates
vertebrate
vessel
blood
arteries
vertebrates
Arteries
aorta
Alligators and Crocodiles
Lampreys
Sharks
Rana catesbeiana
Lithobates catesbeianus
gills
Petromyzontiformes

ASJC Scopus subject areas

  • Physiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Animal Science and Zoology
  • Genetics

Cite this

Effects of hypoxia on vertebrate blood vessels. / Russell, Michael James; Dombkowski, Ryan A.; Olson, Kenneth R.

In: Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, Vol. 309, No. 2, 01.03.2008, p. 55-63.

Research output: Contribution to journalArticle

Russell, Michael James ; Dombkowski, Ryan A. ; Olson, Kenneth R. / Effects of hypoxia on vertebrate blood vessels. In: Journal of Experimental Zoology Part A: Ecological Genetics and Physiology. 2008 ; Vol. 309, No. 2. pp. 55-63.
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