Effects of induced premaxillary suture fusion on the craniofacial morphology in growing rats

Wen hua Ruan, Julia N. Winger, Jack C Yu, James L. Borke

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: Due to premaxillary rapid development and fusion with the maxilla at the fetus stage, the functions of the premaxillary suture still remain unclear. This study was designed to explore the effect of artificial induced premaxillary suture fusion on craniofacial morphology. Methods: Thirty Sprague Dawley rats were divided into control and experimental groups, with 3 week, 5 week and 8 week subgroups of five animals each. An incision was made in each rat along the premaxillary suture and cyanoacrylate was administered to immobilize the exposed premaxillary suture for experimental rats. No glue was applied to controls. Weights, dental impressions and radiographs were taken before and after surgery until sacrifice and used to determine the differences between groups using the one-way ANOVA test. Results: After immobilizing the premaxillary suture, significant changes in the craniofacial morphology were measured at the different time points. In the experimental groups, local changes occurred at the 3rd week. A global alteration in craniofacial morphology was apparent at the 8th week in the experimental group compared to the control. At each successive time point, craniofacial morphological alterations increased in rats with fused premaxillary sutures. Conclusions: Induced premaxillary suture fusion can inhibit the growth of the premaxilla and cause extensive craniofacial morphological changes. These findings suggest that premaxillary suture fusion may be related to craniofacial malformation or malocclusion and to the formation of the flattened craniofacial profile in humans.

Original languageEnglish (US)
Pages (from-to)79-86
Number of pages8
JournalArchives of Oral Biology
Volume53
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

Sutures
Cyanoacrylates
Malocclusion
Maxilla
Adhesives
Sprague Dawley Rats
Analysis of Variance
Tooth
Fetus
Weights and Measures
Control Groups
Growth

Keywords

  • Animal experiment
  • Craniofacial morphology
  • Premaxillary suture fusion

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Cite this

Effects of induced premaxillary suture fusion on the craniofacial morphology in growing rats. / Ruan, Wen hua; Winger, Julia N.; Yu, Jack C; Borke, James L.

In: Archives of Oral Biology, Vol. 53, No. 1, 01.01.2008, p. 79-86.

Research output: Contribution to journalArticle

Ruan, Wen hua ; Winger, Julia N. ; Yu, Jack C ; Borke, James L. / Effects of induced premaxillary suture fusion on the craniofacial morphology in growing rats. In: Archives of Oral Biology. 2008 ; Vol. 53, No. 1. pp. 79-86.
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