Effects of labetalol on hemodynamics and seizure duration during ECT

William Vaughn McCall, F. E. Shelp, R. D. Weiner, S. Austin, A. Harrill

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Beta blockers are commonly used to attenuate the transient increase in heart rate (HR) and blood pressure (BP) that accompany electroconvulsive therapy (ECT). Recent reports have suggested that several beta blockers have anticonvulsant properties and hence could be countertherapeutic with ECT. In a randomized, double-blind controlled study of the dose response effects of intravenous labetalol on ECT hemodynamics and seizure duration, labetalol exhibited dose-dependent reduction in HR and rate pressure product (RPP) at the 5 and 10 mg doses compared to placebo. However, no significant differences between labetalol 5 mg, 10 mg, or placebo were found on BP or seizure duration.

Original languageEnglish (US)
Pages (from-to)5-14
Number of pages10
JournalConvulsive Therapy
Volume7
Issue number1
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Labetalol
Electroconvulsive Therapy
Seizures
Hemodynamics
Heart Rate
Placebos
Blood Pressure
Double-Blind Method
Anticonvulsants
Pressure

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

McCall, W. V., Shelp, F. E., Weiner, R. D., Austin, S., & Harrill, A. (1991). Effects of labetalol on hemodynamics and seizure duration during ECT. Convulsive Therapy, 7(1), 5-14.

Effects of labetalol on hemodynamics and seizure duration during ECT. / McCall, William Vaughn; Shelp, F. E.; Weiner, R. D.; Austin, S.; Harrill, A.

In: Convulsive Therapy, Vol. 7, No. 1, 01.01.1991, p. 5-14.

Research output: Contribution to journalArticle

McCall, WV, Shelp, FE, Weiner, RD, Austin, S & Harrill, A 1991, 'Effects of labetalol on hemodynamics and seizure duration during ECT', Convulsive Therapy, vol. 7, no. 1, pp. 5-14.
McCall WV, Shelp FE, Weiner RD, Austin S, Harrill A. Effects of labetalol on hemodynamics and seizure duration during ECT. Convulsive Therapy. 1991 Jan 1;7(1):5-14.
McCall, William Vaughn ; Shelp, F. E. ; Weiner, R. D. ; Austin, S. ; Harrill, A. / Effects of labetalol on hemodynamics and seizure duration during ECT. In: Convulsive Therapy. 1991 ; Vol. 7, No. 1. pp. 5-14.
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