Effects of left atrial and airway pressures on airway blood flow

S. A. Barman, J. L. Ardell, A. E. Taylor

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The blood flow contributions of the pulmonary and systemic circulations to airway blood flow from the trachea down to the 5th generation airways when either 15 cmH2O positive end expiratory pressure (PEEP) or 20 mmHg left atrial pressure was applied were assessed in anesthetized dogs by injecting 15-μm radiolabeled microspheres into the right and left heart, respectively. After the microsphere injections, the animals were killed, and the tracheal cartilage, tracheal muscle-mucosa, main bronchi and the 2nd generaion bronchi down to the 5th generation airways were excised and collected for radioactive counting. The results of this study showed that under normal conditions, tracheal blood flow was primarily systemic (> 95% of total tracheal blood flow) averaging 15-26ml·min-1·(100 g)-1, while both the pulmonary [10 ml·min-1·(100 g)-1] and systematic circulations [15 ml·min-1·(100 g)-1] contributed substantially to main bronchi blood flow. The systemic blood flow contribution to the lower airway generations (2nd to the 5th generation airways) stayed relatively constant, averaging 13-31 ml·min·(100 g)-1 while the pulmonary blood flow contribution increased significantly in these airway segments to a maximum of over 100 ml·min-1·(100 g)-1 at the 5th generation. At 15 cmH2O PEEP, the systematic contribution to all of the airway segments (except the 5th generation, P < 0.09) and the pulmonary component to the main bronchi, significantly decreased (P < 0.05). In contrast, elevated left atrial pressure had little effect on the pulmonary and systemic contributions to airway blood flow. The results of this study suggest that elevated PEEP has a greater effect than elevated left atrial pressure on the systemic blood flow contribution to the airways, while the pulmonary blood flow contribution to the airways is affected very little by either of these perturbations.

Original languageEnglish (US)
Pages (from-to)61-74
Number of pages14
JournalRespiration Physiology
Volume94
Issue number1
DOIs
StatePublished - Oct 1993

Fingerprint

Atrial Pressure
Bronchi
Positive-Pressure Respiration
Lung
Microspheres
Pulmonary Circulation
Trachea
Cartilage
Mucous Membrane
Dogs
Muscles
Injections

Keywords

  • Blood flow, bronchial, origin
  • Bronchi, blood flow
  • Mammals, dog
  • Perfusion, bronchi

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Effects of left atrial and airway pressures on airway blood flow. / Barman, S. A.; Ardell, J. L.; Taylor, A. E.

In: Respiration Physiology, Vol. 94, No. 1, 10.1993, p. 61-74.

Research output: Contribution to journalArticle

Barman, S. A. ; Ardell, J. L. ; Taylor, A. E. / Effects of left atrial and airway pressures on airway blood flow. In: Respiration Physiology. 1993 ; Vol. 94, No. 1. pp. 61-74.
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abstract = "The blood flow contributions of the pulmonary and systemic circulations to airway blood flow from the trachea down to the 5th generation airways when either 15 cmH2O positive end expiratory pressure (PEEP) or 20 mmHg left atrial pressure was applied were assessed in anesthetized dogs by injecting 15-μm radiolabeled microspheres into the right and left heart, respectively. After the microsphere injections, the animals were killed, and the tracheal cartilage, tracheal muscle-mucosa, main bronchi and the 2nd generaion bronchi down to the 5th generation airways were excised and collected for radioactive counting. The results of this study showed that under normal conditions, tracheal blood flow was primarily systemic (> 95{\%} of total tracheal blood flow) averaging 15-26ml·min-1·(100 g)-1, while both the pulmonary [10 ml·min-1·(100 g)-1] and systematic circulations [15 ml·min-1·(100 g)-1] contributed substantially to main bronchi blood flow. The systemic blood flow contribution to the lower airway generations (2nd to the 5th generation airways) stayed relatively constant, averaging 13-31 ml·min·(100 g)-1 while the pulmonary blood flow contribution increased significantly in these airway segments to a maximum of over 100 ml·min-1·(100 g)-1 at the 5th generation. At 15 cmH2O PEEP, the systematic contribution to all of the airway segments (except the 5th generation, P < 0.09) and the pulmonary component to the main bronchi, significantly decreased (P < 0.05). In contrast, elevated left atrial pressure had little effect on the pulmonary and systemic contributions to airway blood flow. The results of this study suggest that elevated PEEP has a greater effect than elevated left atrial pressure on the systemic blood flow contribution to the airways, while the pulmonary blood flow contribution to the airways is affected very little by either of these perturbations.",
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