Effects of methylphenidate on cardiovascular responses in attention deficit hyperactivity disordered adolescents

Ronald T. Brown, Sandra B. Sexson

Research output: Contribution to journalArticle

21 Scopus citations


The short-term dose effects of methylphenidate were examined on cardiovascular measures in 11 black male adolescents diagnosed as having attention deficit hyperactivity disorder (ADHD). In a double-blind, crossover design with randomized order, the subjects received placebo and each of three methylphenidate doses (0.15, 0.3, and 0.5 mg/kg) for a period of 2 weeks per medication dosage. Significant main effects were found for diastolic and systolic blood pressure; however, pairwise comparisons revealed a significant linear increase in diastolic blood pressure only. Because of the unexpected increase in diastolic blood pressure, careful monitoring of black adolescents who are receiving methylphenidate is recommended.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalJournal of Adolescent Health Care
Issue number3
Publication statusPublished - May 1989
Externally publishedYes



  • Attention deficit hyperactivity disorder Blood pressure Methylphenidate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health

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