Effects of methylphenidate on cardiovascular responses in attention deficit hyperactivity disordered adolescents

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The short-term dose effects of methylphenidate were examined on cardiovascular measures in 11 black male adolescents diagnosed as having attention deficit hyperactivity disorder (ADHD). In a double-blind, crossover design with randomized order, the subjects received placebo and each of three methylphenidate doses (0.15, 0.3, and 0.5 mg/kg) for a period of 2 weeks per medication dosage. Significant main effects were found for diastolic and systolic blood pressure; however, pairwise comparisons revealed a significant linear increase in diastolic blood pressure only. Because of the unexpected increase in diastolic blood pressure, careful monitoring of black adolescents who are receiving methylphenidate is recommended.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalJournal of Adolescent Health Care
Volume10
Issue number3
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Methylphenidate
Blood Pressure
Attention Deficit Disorder with Hyperactivity
Cross-Over Studies
Placebos

Keywords

  • Attention deficit hyperactivity disorder Blood pressure Methylphenidate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health

Cite this

Effects of methylphenidate on cardiovascular responses in attention deficit hyperactivity disordered adolescents. / Brown, Ronald T.; Sexson, Sandra Griffin Bishop.

In: Journal of Adolescent Health Care, Vol. 10, No. 3, 01.01.1989, p. 179-183.

Research output: Contribution to journalArticle

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