Effects of Mycobacterium avium complex-infection treatment on cytokine expression in human immunodeficiency virus-infected persons: Results of AIDS Clinical Trials Group Protocol 853

Rodger D. MacArthur, Michael M. Lederman, Constance A. Benson, Miriam C. Chernoff, Rob Roy MacGregor, John Spritzler, Laura F. Mahon, Belinda Yen-Lieberman, Scott Purvis

Research output: Contribution to journalArticle

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Abstract

Human immunodeficiency virus (HIV) type 1-infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8- week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens were obtained for quantitative MAC cultures and to determine plasma levels of HIV RNA, TNF-α, and other proinflammatory cytokines. MAC levels decreased by 1.75 log at week 4 (P = .008) and by 2.48 log at week 8 (P = .001). Plasma TNF-α decreased by 0.15 log at week 4 (P = .042) and by 0.40 log at week 8 (P = .027). Plasma interleukin (IL)-6 decreased by 0.56 log at week 8 (P = .039). There were nonsignificant trends (P < .10) for plasma levels of IL-1β and HIV RNA to decrease at week 8. Nonsignificant decreases in plasma levels of TNF-α, IL-1β, ID-6, and HIV RNA were also seen in those individuals who remained on stable antiretroviral therapy throughout the 8 weeks of the study.

Original languageEnglish (US)
Pages (from-to)1486-1490
Number of pages5
JournalJournal of Infectious Diseases
Volume181
Issue number4
DOIs
StatePublished - May 22 2000

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Mycobacterium avium Complex
Clinical Protocols
Acquired Immunodeficiency Syndrome
Clinical Trials
HIV
Cytokines
Tumor Necrosis Factor-alpha
Infection
RNA
Interleukin-1
Therapeutics
Bacteremia
HIV-1
Interleukin-6

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Effects of Mycobacterium avium complex-infection treatment on cytokine expression in human immunodeficiency virus-infected persons : Results of AIDS Clinical Trials Group Protocol 853. / MacArthur, Rodger D.; Lederman, Michael M.; Benson, Constance A.; Chernoff, Miriam C.; MacGregor, Rob Roy; Spritzler, John; Mahon, Laura F.; Yen-Lieberman, Belinda; Purvis, Scott.

In: Journal of Infectious Diseases, Vol. 181, No. 4, 22.05.2000, p. 1486-1490.

Research output: Contribution to journalArticle

MacArthur, Rodger D. ; Lederman, Michael M. ; Benson, Constance A. ; Chernoff, Miriam C. ; MacGregor, Rob Roy ; Spritzler, John ; Mahon, Laura F. ; Yen-Lieberman, Belinda ; Purvis, Scott. / Effects of Mycobacterium avium complex-infection treatment on cytokine expression in human immunodeficiency virus-infected persons : Results of AIDS Clinical Trials Group Protocol 853. In: Journal of Infectious Diseases. 2000 ; Vol. 181, No. 4. pp. 1486-1490.
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