Effects of Mycobacterium avium complex-infection treatment on cytokine expression in human immunodeficiency virus-infected persons: Results of AIDS Clinical Trials Group Protocol 853

Rodger D. MacArthur, Michael M. Lederman, Constance A. Benson, Miriam C. Chernoff, Rob Roy MacGregor, John Spritzler, Laura F. Mahon, Belinda Yen-Lieberman, Scott Purvis

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6 Scopus citations

Abstract

Human immunodeficiency virus (HIV) type 1-infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8- week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens were obtained for quantitative MAC cultures and to determine plasma levels of HIV RNA, TNF-α, and other proinflammatory cytokines. MAC levels decreased by 1.75 log at week 4 (P = .008) and by 2.48 log at week 8 (P = .001). Plasma TNF-α decreased by 0.15 log at week 4 (P = .042) and by 0.40 log at week 8 (P = .027). Plasma interleukin (IL)-6 decreased by 0.56 log at week 8 (P = .039). There were nonsignificant trends (P < .10) for plasma levels of IL-1β and HIV RNA to decrease at week 8. Nonsignificant decreases in plasma levels of TNF-α, IL-1β, ID-6, and HIV RNA were also seen in those individuals who remained on stable antiretroviral therapy throughout the 8 weeks of the study.

Original languageEnglish (US)
Pages (from-to)1486-1490
Number of pages5
JournalJournal of Infectious Diseases
Volume181
Issue number4
DOIs
Publication statusPublished - May 22 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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