Effects of progressive resistance training on immune response in aging and chronic inflammation

Laura C. Rall, Ronenn Roubenoff, Joseph Gerard Cannon, Leslie W. Abad, Charles A. Dinarello, Simin Nikbin Meydani

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

The effects of 12 wk of progressive resistance strength training on in vivo and in vitro immune parameters were evaluated in a controlled study of eight subjects with rheumatoid arthritis (RA), eight healthy young (22-30 yr), and eight healthy elderly (65-80 yr) individuals. Six healthy elderly (65-80 yr) nontraining control subjects were also evaluated to account for seasonal and psychosocial effects. Training subjects exercised at 80% of their one-repetition maximum and performed eight repetitions per set, three sets per session on a twice weekly basis. Peripheral blood mononuclear cell (PBMC) subpopulations, cytokine and prostaglandin (PG) E2 production, proliferative response, and delayed type hypersensitivity (DTH) skin response were measured before and after 12 wk of training. Training did not induce changes in PBMC subsets, interleukin (IL)-1 β, tumor necrosis factor-α (TNF), IL-6, IL-2, or PGE2 production, lymphocyte proliferation, or DTH response in any of the training groups compared with control subjects. These data suggest that 12 wk of high-intensity progressive resistance strength training does not affect immune function in young or elderly healthy individuals or subjects with RA.

Original languageEnglish (US)
Pages (from-to)1356-1365
Number of pages10
JournalMedicine and Science in Sports and Exercise
Volume28
Issue number11
DOIs
StatePublished - Jan 1 1996

Fingerprint

Resistance Training
Inflammation
Delayed Hypersensitivity
Dinoprostone
Blood Cells
Rheumatoid Arthritis
Interleukin-1
Interleukin-2
Interleukin-6
Tumor Necrosis Factor-alpha
Lymphocytes
Cytokines
Skin

Keywords

  • CYTOKINES
  • EXERCISE
  • INFLAMMATION
  • LYMPHOCYTES

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effects of progressive resistance training on immune response in aging and chronic inflammation. / Rall, Laura C.; Roubenoff, Ronenn; Cannon, Joseph Gerard; Abad, Leslie W.; Dinarello, Charles A.; Meydani, Simin Nikbin.

In: Medicine and Science in Sports and Exercise, Vol. 28, No. 11, 01.01.1996, p. 1356-1365.

Research output: Contribution to journalArticle

Rall, Laura C. ; Roubenoff, Ronenn ; Cannon, Joseph Gerard ; Abad, Leslie W. ; Dinarello, Charles A. ; Meydani, Simin Nikbin. / Effects of progressive resistance training on immune response in aging and chronic inflammation. In: Medicine and Science in Sports and Exercise. 1996 ; Vol. 28, No. 11. pp. 1356-1365.
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