Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zucker rats

Miriam Yvette Cortez-Cooper, Carol E. Torgan, Joseph T. Brozinick, Robert H. Miller, John L. Ivy

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Female obese Zucker rats (aged 6 wk) were randomly assigned to one of two control or one of three experimental-diet groups. Experimental diets contained 6% pyruvate (Pyr), 6% dihydroxyacetone (Dha), or 3% each pyruvate and dihydroxyacetone (Pyr-Dha). Control-group 1 was fed a normal diet ad libitum and control-group 2 was pair fed according to the experimental group with the lowest consumption. After 5 wk the rats receiving Pyr (357.5 ± 12.7 g) were significantly lighter than pair-fed (385.9 ± 4.9 g) and ad libitum-fed (404.3 ± 10.1) controls. Resting oxygen consumption (mL·min-1·kg0.65) was significantly higher in Pyr-fed rats than in pair-fed controls and food-conversion efficiency was significantly decreased. Rats fed Pyr had a lower resting respiratory-exchange ratio than did ad libitum- and pair-fed controls (0.81 ± 0.01 vs 0.88 ± 0.01 and 0.87 ± 0.01, respectively). Results suggest that pyruvate consumption reduced the weight gain and food-conversion efficiency of obese Zucker rats, in part by increasing resting metabolic rate and fatty acid oxidation.

Original languageEnglish (US)
Pages (from-to)847-853
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Issue number4
Publication statusPublished - Jan 1 1991



  • Dihydroxyacetone
  • Hepatic steatosis
  • Oxygen consumption
  • Pyruvate
  • Resting metabolic rate

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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