Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zucker rats

Miriam Y. Cortez, Carol E. Torgan, Joseph T. Brozinick, Robert H. Miller, John L. Ivy

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Female obese Zucker rats (aged 6 wk) were randomly assigned to one of two control or one of three experimental-diet groups. Experimental diets contained 6% pyruvate (Pyr), 6% dihydroxyacetone (Dha), or 3% each pyruvate and dihydroxyacetone (Pyr-Dha). Control-group 1 was fed a normal diet ad libitum and control-group 2 was pair fed according to the experimental group with the lowest consumption. After 5 wk the rats receiving Pyr (357.5 ± 12.7 g) were significantly lighter than pair-fed (385.9 ± 4.9 g) and ad libitum-fed (404.3 ± 10.1) controls. Resting oxygen consumption (mL·min-1·kg0.65) was significantly higher in Pyr-fed rats than in pair-fed controls and food-conversion efficiency was significantly decreased. Rats fed Pyr had a lower resting respiratory-exchange ratio than did ad libitum- and pair-fed controls (0.81 ± 0.01 vs 0.88 ± 0.01 and 0.87 ± 0.01, respectively). Results suggest that pyruvate consumption reduced the weight gain and food-conversion efficiency of obese Zucker rats, in part by increasing resting metabolic rate and fatty acid oxidation.

Original languageEnglish (US)
Pages (from-to)847-853
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume53
Issue number4
DOIs
StatePublished - Apr 1991

Keywords

  • Dihydroxyacetone
  • Hepatic steatosis
  • Oxygen consumption
  • Pyruvate
  • Resting metabolic rate

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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