TY - JOUR
T1 - Effects of pyruvate on the metabolism and insulin resistance of obese Zucker rats
AU - Ivy, John L.
AU - Cortez, Miriam Y.
AU - Chandler, Resa M.
AU - Byrne, Heidi K.
AU - Miller, Robert H.
PY - 1994/2
Y1 - 1994/2
N2 - Female obese Zucker rats aged 5 wk were randomly assigned to a control diet or one of two experimental diets. Experimental diets contained 6% of energy as pyruvate in the form of calcium-pyruvate (Ca-pyr) or 6% pyruvylglycine (pyr-gly). Diets were pair-fed according to the experimental group with the lowest food consumption. During the 3 wk of dietary treatment, Ca-pyr- and pyr-gly-fed rats gained significantly less weight, had a lower food-conversion efficiency, and maintained a higher resting oxygen consumption (mL · min-1 · kg-0.67) than control rats. Ca-pyr and pyr-gly also lowered the respiratory exchange ratio of the rats resulting in a 90% increase in their lipid oxidation and a 50% decrease in their carbohydrate oxidation. Glucose tolerance, assessed by an oral glucose load, was not different among treatments, but the insulin response of the pyr-gly- fed rats was significantly less than that of the control rats despite elevated plasma triglyceride concentrations in the pyr-gly-fed rats (control, 1.43 ± 0.16 vs pyr-gly, 3.76 ± 0.87 mmol/L). These results suggest that pyr-gly, like Ca-pyr, favorably alters the metabolism of obese Zucker rats. In addition, pyr-gly appeared to reduce the insulin resistance that develops spontaneously in obese rats.
AB - Female obese Zucker rats aged 5 wk were randomly assigned to a control diet or one of two experimental diets. Experimental diets contained 6% of energy as pyruvate in the form of calcium-pyruvate (Ca-pyr) or 6% pyruvylglycine (pyr-gly). Diets were pair-fed according to the experimental group with the lowest food consumption. During the 3 wk of dietary treatment, Ca-pyr- and pyr-gly-fed rats gained significantly less weight, had a lower food-conversion efficiency, and maintained a higher resting oxygen consumption (mL · min-1 · kg-0.67) than control rats. Ca-pyr and pyr-gly also lowered the respiratory exchange ratio of the rats resulting in a 90% increase in their lipid oxidation and a 50% decrease in their carbohydrate oxidation. Glucose tolerance, assessed by an oral glucose load, was not different among treatments, but the insulin response of the pyr-gly- fed rats was significantly less than that of the control rats despite elevated plasma triglyceride concentrations in the pyr-gly-fed rats (control, 1.43 ± 0.16 vs pyr-gly, 3.76 ± 0.87 mmol/L). These results suggest that pyr-gly, like Ca-pyr, favorably alters the metabolism of obese Zucker rats. In addition, pyr-gly appeared to reduce the insulin resistance that develops spontaneously in obese rats.
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U2 - 10.1093/ajcn/59.2.331
DO - 10.1093/ajcn/59.2.331
M3 - Article
C2 - 8310982
AN - SCOPUS:0028089331
SN - 0002-9165
VL - 59
SP - 331
EP - 337
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 2
ER -