Effects of pyruvate on the metabolism and insulin resistance of obese Zucker rats

John L. Ivy, Miriam Yvette Cortez-Cooper, Resa M. Chandler, Heidi K. Byrne, Robert H. Miller

Research output: Contribution to journalArticle

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Abstract

Female obese Zucker rats aged 5 wk were randomly assigned to a control diet or one of two experimental diets. Experimental diets contained 6% of energy as pyruvate in the form of calcium-pyruvate (Ca-pyr) or 6% pyruvylglycine (pyr-gly). Diets were pair-fed according to the experimental group with the lowest food consumption. During the 3 wk of dietary treatment, Ca-pyr- and pyr-gly-fed rats gained significantly less weight, had a lower food-conversion efficiency, and maintained a higher resting oxygen consumption (mL · min-1 · kg-0.67) than control rats. Ca-pyr and pyr-gly also lowered the respiratory exchange ratio of the rats resulting in a 90% increase in their lipid oxidation and a 50% decrease in their carbohydrate oxidation. Glucose tolerance, assessed by an oral glucose load, was not different among treatments, but the insulin response of the pyr-gly- fed rats was significantly less than that of the control rats despite elevated plasma triglyceride concentrations in the pyr-gly-fed rats (control, 1.43 ± 0.16 vs pyr-gly, 3.76 ± 0.87 mmol/L). These results suggest that pyr-gly, like Ca-pyr, favorably alters the metabolism of obese Zucker rats. In addition, pyr-gly appeared to reduce the insulin resistance that develops spontaneously in obese rats.

Original languageEnglish (US)
Pages (from-to)331-337
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume59
Issue number2
DOIs
StatePublished - Jan 1 1994

Fingerprint

Zucker Rats
Pyruvic Acid
Insulin Resistance
Diet
Glucose Tolerance Test
Calcium
Dietary Calcium
Food
pyruvylglycine
Oxygen Consumption
Triglycerides
Carbohydrates
Insulin
Lipids
Weights and Measures

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Ivy, J. L., Cortez-Cooper, M. Y., Chandler, R. M., Byrne, H. K., & Miller, R. H. (1994). Effects of pyruvate on the metabolism and insulin resistance of obese Zucker rats. American Journal of Clinical Nutrition, 59(2), 331-337. https://doi.org/10.1093/ajcn/59.2.331

Effects of pyruvate on the metabolism and insulin resistance of obese Zucker rats. / Ivy, John L.; Cortez-Cooper, Miriam Yvette; Chandler, Resa M.; Byrne, Heidi K.; Miller, Robert H.

In: American Journal of Clinical Nutrition, Vol. 59, No. 2, 01.01.1994, p. 331-337.

Research output: Contribution to journalArticle

Ivy, JL, Cortez-Cooper, MY, Chandler, RM, Byrne, HK & Miller, RH 1994, 'Effects of pyruvate on the metabolism and insulin resistance of obese Zucker rats', American Journal of Clinical Nutrition, vol. 59, no. 2, pp. 331-337. https://doi.org/10.1093/ajcn/59.2.331
Ivy, John L. ; Cortez-Cooper, Miriam Yvette ; Chandler, Resa M. ; Byrne, Heidi K. ; Miller, Robert H. / Effects of pyruvate on the metabolism and insulin resistance of obese Zucker rats. In: American Journal of Clinical Nutrition. 1994 ; Vol. 59, No. 2. pp. 331-337.
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