Abstract
This paper examines the effects of smoking on the treatment outcomes of two nonsurgical therapies: (1) scaling and root planing alone (SRP) or (2) controlled-release of subgingivally delivered doxycycline hyclate in a polylactic acid based polymer gel. Subjects from 2 9-month multicenter studies were classified as nonsmokers (never smoked: 100 subjects), former smokers (137 subjects), and current smokers (≥ 10 cigarettes/day: 121 subjects). Clinical parameters were analyzed for treated sites with baseline probing depths ≥5 mm and for a subset of treated sites with baseline probing depths of ≥7 mm. Clinical parameters (plaque levels, clinical attachment levels, pocket depths, and bleeding on probing) were analyzed at baseline, 4, 6, and 9 months. In the doxycycline treated group in general, there were neither marked significant differences in clinical attachment gain nor differences in probing depth reduction among the 3 smoking groups. On the other hand, in the scaling and root planing treated group in general, there were significant differences in clinical attachment gain and pocket depth reduction, with non-smokers responding better than former smokers and current smokers at 6 and 9 months. These differences in clinical response between scaling and root planing alone versus controlled-release of locally-delivered doxycycline hyclate among these 3 smoking groups are discussed in relation to treatment implications for smokers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 683-691 |
| Number of pages | 9 |
| Journal | Journal of Clinical Periodontology |
| Volume | 26 |
| Issue number | 10 |
| DOIs | |
| State | Published - Jan 1 1999 |
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Keywords
- Doxycycline
- Local delivery
- Periodontitis
- Scaling/root planing
- Tobacco
ASJC Scopus subject areas
- Periodontics
Cite this
Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing. / Ryder, Mark I.; Pons, Barbara; Adams, Donald; Beiswanger, Bradley; Blanco, Valerie; Bogle, Gary; Donly, Kevin; Hallmon, William; Hancock, E. Brady; Hanes, Philip Jerry; Hawley, Charles; Johnson, Lonnie; Wang, Horn Lay; Wolinsky, Lawrence; Yukna, Raymond; Polson, Alan; Carron, Graham; Garrett, Steven.
In: Journal of Clinical Periodontology, Vol. 26, No. 10, 01.01.1999, p. 683-691.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing
AU - Ryder, Mark I.
AU - Pons, Barbara
AU - Adams, Donald
AU - Beiswanger, Bradley
AU - Blanco, Valerie
AU - Bogle, Gary
AU - Donly, Kevin
AU - Hallmon, William
AU - Hancock, E. Brady
AU - Hanes, Philip Jerry
AU - Hawley, Charles
AU - Johnson, Lonnie
AU - Wang, Horn Lay
AU - Wolinsky, Lawrence
AU - Yukna, Raymond
AU - Polson, Alan
AU - Carron, Graham
AU - Garrett, Steven
PY - 1999/1/1
Y1 - 1999/1/1
N2 - This paper examines the effects of smoking on the treatment outcomes of two nonsurgical therapies: (1) scaling and root planing alone (SRP) or (2) controlled-release of subgingivally delivered doxycycline hyclate in a polylactic acid based polymer gel. Subjects from 2 9-month multicenter studies were classified as nonsmokers (never smoked: 100 subjects), former smokers (137 subjects), and current smokers (≥ 10 cigarettes/day: 121 subjects). Clinical parameters were analyzed for treated sites with baseline probing depths ≥5 mm and for a subset of treated sites with baseline probing depths of ≥7 mm. Clinical parameters (plaque levels, clinical attachment levels, pocket depths, and bleeding on probing) were analyzed at baseline, 4, 6, and 9 months. In the doxycycline treated group in general, there were neither marked significant differences in clinical attachment gain nor differences in probing depth reduction among the 3 smoking groups. On the other hand, in the scaling and root planing treated group in general, there were significant differences in clinical attachment gain and pocket depth reduction, with non-smokers responding better than former smokers and current smokers at 6 and 9 months. These differences in clinical response between scaling and root planing alone versus controlled-release of locally-delivered doxycycline hyclate among these 3 smoking groups are discussed in relation to treatment implications for smokers.
AB - This paper examines the effects of smoking on the treatment outcomes of two nonsurgical therapies: (1) scaling and root planing alone (SRP) or (2) controlled-release of subgingivally delivered doxycycline hyclate in a polylactic acid based polymer gel. Subjects from 2 9-month multicenter studies were classified as nonsmokers (never smoked: 100 subjects), former smokers (137 subjects), and current smokers (≥ 10 cigarettes/day: 121 subjects). Clinical parameters were analyzed for treated sites with baseline probing depths ≥5 mm and for a subset of treated sites with baseline probing depths of ≥7 mm. Clinical parameters (plaque levels, clinical attachment levels, pocket depths, and bleeding on probing) were analyzed at baseline, 4, 6, and 9 months. In the doxycycline treated group in general, there were neither marked significant differences in clinical attachment gain nor differences in probing depth reduction among the 3 smoking groups. On the other hand, in the scaling and root planing treated group in general, there were significant differences in clinical attachment gain and pocket depth reduction, with non-smokers responding better than former smokers and current smokers at 6 and 9 months. These differences in clinical response between scaling and root planing alone versus controlled-release of locally-delivered doxycycline hyclate among these 3 smoking groups are discussed in relation to treatment implications for smokers.
KW - Doxycycline
KW - Local delivery
KW - Periodontitis
KW - Scaling/root planing
KW - Tobacco
UR - http://www.scopus.com/inward/record.url?scp=0033209702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033209702&partnerID=8YFLogxK
U2 - 10.1034/j.1600-051X.1999.261008.x
DO - 10.1034/j.1600-051X.1999.261008.x
M3 - Article
C2 - 10522780
AN - SCOPUS:0033209702
VL - 26
SP - 683
EP - 691
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
SN - 0303-6979
IS - 10
ER -