Effects of vitamin D insufficiency on bone mineral density in African American men

N. Akhter, Bridget Sinnott, K. Mahmood, S. Rao, S. Kukreja, E. Barengolts

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

In African American men serum, 25-hydroxyvitamin D (25-OHD) was below 30 ng/ml in 89% of subjects. In overall group, there was no correlation between 25-OHD and bone mineral density (BMD). A subgroup analysis of subjects with 25-OHD ≤ 15 ng/ml showed that serum 25-OHD was positively associated with BMD. Introduction: This study examined the effects of low serum 25-hydroxyvitamin D (25-OHD) on bone mineral density (BMD) in African American (AA) men from the general medicine clinic at an inner city Veteran Administration medical center. Methods: The data for 112 AA males who had both 25-OHD levels and BMD of spine and hip were extracted and analyzed using SAS software. Results: AA men were aged 38 to 85 years, with mean age of 62 years. Levels of 25-OHD ranged from 4 to 45 ng/ml, with mean 17.5 ng/ml, 24% and 89% of the subjects had 25-OHD below 10 and 30 ng/ml, respectively. In the overall group, there was no correlation between 25-OHD and BMD at any site. In a subgroup analysis of subjects with 25-OHD 15 ng/ml, in multiple adjusted models, 25-OHD was positively associated with BMD of spine (r∈=∈0.26, p∈=∈0.05), total hip (r∈=∈0.27, p∈<∈0.05), ward's triangle (r∈=∈0.25, p∈=∈0.05), and trochanter (r∈=∈0.30, p∈<∈0.05). Conclusions: The negative effect of vitamin D insufficiency on bone was observed only at very low levels of 25-OHD, suggesting that AA male skeleton is relatively resistant to the effects of secondary hyperparathyroidism.

Original languageEnglish (US)
Pages (from-to)745-750
Number of pages6
JournalOsteoporosis International
Volume20
Issue number5
DOIs
StatePublished - May 1 2009
Externally publishedYes

Keywords

  • African American men
  • Low bone mass
  • Vitamin D insufficiency

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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