TY - JOUR
T1 - Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model
AU - Chandrasekar, P. H.
AU - Cutright, Jessica
AU - Manavathu, Elias
PY - 2000
Y1 - 2000
N2 - We compared the efficacies of amphotericin B and voriconazole against invasive pulmonary aspergillosis in a guinea-pig model. A susceptible isolate of Aspergillus fumigatus was used to produce the infection. Voriconazole-treated animals had significantly better survival and decreased fungal burden in the lungs as compared with controls. Although no statistical difference was seen between the efficacies of voriconazole and amphotericin B, a trend favouring voriconazole was noted. Thus, voriconazole, with its cidal activity, may be an attractive alternative to potentially toxic amphotericin B in the treatment of invasive pulmonary aspergillosis.
AB - We compared the efficacies of amphotericin B and voriconazole against invasive pulmonary aspergillosis in a guinea-pig model. A susceptible isolate of Aspergillus fumigatus was used to produce the infection. Voriconazole-treated animals had significantly better survival and decreased fungal burden in the lungs as compared with controls. Although no statistical difference was seen between the efficacies of voriconazole and amphotericin B, a trend favouring voriconazole was noted. Thus, voriconazole, with its cidal activity, may be an attractive alternative to potentially toxic amphotericin B in the treatment of invasive pulmonary aspergillosis.
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U2 - 10.1093/jac/45.5.673
DO - 10.1093/jac/45.5.673
M3 - Article
C2 - 10797091
AN - SCOPUS:0034016866
SN - 0305-7453
VL - 45
SP - 673
EP - 676
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 5
ER -
