Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model

P. H. Chandrasekar, Jessica Cutright, Elias Kurian Manavathu

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We compared the efficacies of amphotericin B and voriconazole against invasive pulmonary aspergillosis in a guinea-pig model. A susceptible isolate of Aspergillus fumigatus was used to produce the infection. Voriconazole-treated animals had significantly better survival and decreased fungal burden in the lungs as compared with controls. Although no statistical difference was seen between the efficacies of voriconazole and amphotericin B, a trend favouring voriconazole was noted. Thus, voriconazole, with its cidal activity, may be an attractive alternative to potentially toxic amphotericin B in the treatment of invasive pulmonary aspergillosis.

Original languageEnglish (US)
Pages (from-to)673-676
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume45
Issue number5
StatePublished - May 23 2000

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Invasive Pulmonary Aspergillosis
Guinea Pigs
Amphotericin B
Aspergillus fumigatus
Poisons
Voriconazole
Lung
Infection

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model. / Chandrasekar, P. H.; Cutright, Jessica; Manavathu, Elias Kurian.

In: Journal of Antimicrobial Chemotherapy, Vol. 45, No. 5, 23.05.2000, p. 673-676.

Research output: Contribution to journalArticle

Chandrasekar, PH, Cutright, J & Manavathu, EK 2000, 'Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model', Journal of Antimicrobial Chemotherapy, vol. 45, no. 5, pp. 673-676.
Chandrasekar, P. H. ; Cutright, Jessica ; Manavathu, Elias Kurian. / Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model. In: Journal of Antimicrobial Chemotherapy. 2000 ; Vol. 45, No. 5. pp. 673-676.
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