Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosis

P. H. Chandrasekar, J. L. Cutright, E. K. Manavathu

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

The efficacy of voriconazole in combination with amphotericin B or micafungin was studied in a transiently neutropenic guinea-pig model of invasive pulmonary aspergillosis. Guinea-pigs treated with the antifungal drugs, alone or in two-drug combinations, had an improved survival rate and reduced fungal burden in the lungs compared to untreated control animals. The efficacy of monotherapy and combination therapy was similar; activity was neither enhanced nor reduced with the two-drug combinations. Further studies of efficacy, dosing and optimal regimens for antifungal combinations are warranted.

Original languageEnglish (US)
Pages (from-to)925-928
Number of pages4
JournalClinical Microbiology and Infection
Volume10
Issue number10
DOIs
StatePublished - Oct 2004

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Keywords

  • Amphotericin B
  • Aspergillosis
  • Guinea-pig model
  • Micafungin
  • Pulmonary aspergillosis
  • Voriconazole

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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