Efficient Synthesis and Computational Studies of Useful Guanylating Agents: 1H-Benzotriazole-1-carboximidamides

Riham M. Bokhtia, Siva S. Panda, Adel S. Girgis, Girinath G. Pillai, Tarek S. Ibrahim, El Sayed M. Shalaby, Lara Gigli, Eatedal H. Abdel-Aal, Amany M.M. Al-Mahmoudy

Research output: Contribution to journalArticlepeer-review

Abstract

A new synthetic protocol for the synthesis of 1H-benzotriazole-1-carboximidamides starting from aryl amines in presence of acylbenzotriazole has been reported. The versatile guanylating agents could be an efficient synthetic tool for the synthesis of various guanidines. The present approach enables all possible variations of the substituents at different positions of the products. Single crystal of compound 4e was obtained by recrystallization from suitable solvent systems for X-ray and DFT studies. The reaction goes faster and yields more product with higher purity when Cbz protected aminoacyl benzotriazole used instead of aryl benzotriazole for the synthesis of the 1H-benzotriazole-1-carboximidamides. Computational studies were carried out to elucidate the energy profile and transition states to support the experimental data. Short reaction time, simple workup, high yields, and mild conditions are the key advantages of this protocol.

Original languageEnglish (US)
Pages (from-to)13963-13968
Number of pages6
JournalChemistrySelect
Volume5
Issue number44
DOIs
StatePublished - Nov 30 2020

Keywords

  • Amino acids
  • Carboximidamides
  • DFT studies
  • Guanidines
  • X-ray diffraction

ASJC Scopus subject areas

  • Chemistry(all)

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