EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer

Nita Jane Maihle, Jacqueline M. Lafky, Andre T. Baron, Cecelia H. Boardman, Tammy M. Greenwood, Trace A. Christensen, Jill L. Reiter, Elsa M. Cora, Hakjoo Lee, Vera J. Suman, David A. Fishman, Edith A. Perez, Karl C. Podratz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We recently identified several novel transcripts encoding soluble and secreted isoforms of epidermal growth factor receptor (EGFR)/ErbB family members. The EGFR/ErbB family of receptor tyrosine kinases has been implicated in the control of cell growth and differentiation in normal tissues, and the genes encoding these receptors are frequently rearranged and/or overexpressed in a variety of carcinomas. Here, previously published assays useful for the detection of soluble EGFR/ErbB receptor isoforms in human body fluids are briefly reviewed, and results using these assays to analyze sera from breast and ovarian cancer patients are summarized. Together, these results suggest that soluble EGFR/ErbB receptor isoforms are naturally occurring in human circulation, and that they may have clinical utility as both prognostic or diagnostic serum biomarkers in breast and ovarian cancer patients.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalJournal of Clinical Ligand Assay
Volume25
Issue number1
StatePublished - Mar 1 2002
Externally publishedYes

Fingerprint

Biomarkers
Epidermal Growth Factor Receptor
Ovarian Neoplasms
Protein Isoforms
Breast Neoplasms
Serum
Assays
Gene encoding
Body fluids
Receptor Protein-Tyrosine Kinases
Cell growth
Body Fluids
Human Body
Protein-Tyrosine Kinases
Cell Differentiation
Tissue
Carcinoma
Growth
Genes
ErbB Receptors

Keywords

  • Breast cancer
  • Epidermal growth factor receptor (EGFR/ErbB)
  • Ovarian cancer
  • Receptor tyrosine kinases
  • Soluble receptors

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Maihle, N. J., Lafky, J. M., Baron, A. T., Boardman, C. H., Greenwood, T. M., Christensen, T. A., ... Podratz, K. C. (2002). EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer. Journal of Clinical Ligand Assay, 25(1), 57-60.

EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer. / Maihle, Nita Jane; Lafky, Jacqueline M.; Baron, Andre T.; Boardman, Cecelia H.; Greenwood, Tammy M.; Christensen, Trace A.; Reiter, Jill L.; Cora, Elsa M.; Lee, Hakjoo; Suman, Vera J.; Fishman, David A.; Perez, Edith A.; Podratz, Karl C.

In: Journal of Clinical Ligand Assay, Vol. 25, No. 1, 01.03.2002, p. 57-60.

Research output: Contribution to journalArticle

Maihle, NJ, Lafky, JM, Baron, AT, Boardman, CH, Greenwood, TM, Christensen, TA, Reiter, JL, Cora, EM, Lee, H, Suman, VJ, Fishman, DA, Perez, EA & Podratz, KC 2002, 'EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer', Journal of Clinical Ligand Assay, vol. 25, no. 1, pp. 57-60.
Maihle NJ, Lafky JM, Baron AT, Boardman CH, Greenwood TM, Christensen TA et al. EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer. Journal of Clinical Ligand Assay. 2002 Mar 1;25(1):57-60.
Maihle, Nita Jane ; Lafky, Jacqueline M. ; Baron, Andre T. ; Boardman, Cecelia H. ; Greenwood, Tammy M. ; Christensen, Trace A. ; Reiter, Jill L. ; Cora, Elsa M. ; Lee, Hakjoo ; Suman, Vera J. ; Fishman, David A. ; Perez, Edith A. ; Podratz, Karl C. / EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer. In: Journal of Clinical Ligand Assay. 2002 ; Vol. 25, No. 1. pp. 57-60.
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