EGFR role in cancer: A potential therapeutic target

Allyson E. Koyen, Geraldine Nabeta, Stevin Bienfait, Ashley J. Schlafstein, David S. Yu, Waaqo Daddacha

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Protein kinases play a vital role in the regulation of pathways that control cell growth, proliferation, survival, and differentiation. Epidermal growth factor receptor (EGFR) is a key protein kinase that when dysregulated, disrupts these pathways and, accordingly, is associated with several cancers. Thus, EGFR has been a focus of investigation as a therapeutic target for cancer treatment for the past several decades, with fair success. Despite this success, EGFR-targeted therapies are not universally effective across cancers, and improving the specificity and efficiency of EGFR-targeted therapies is an area of continued investigation. This chapter discusses recent progress made in understanding the role of EGFR in cancer and how the knowledge have been used to develop more precise EGFR-based therapeutic regimens for cancer patients.

Original languageEnglish (US)
Title of host publicationRole of Tyrosine Kinases in Gastrointestinal Malignancies
PublisherSpringer Singapore
Pages225-234
Number of pages10
ISBN (Electronic)9789811314865
ISBN (Print)9789811314858
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Keywords

  • Cancer
  • EGFR
  • Protein kinases
  • Receptors
  • Therapy

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Koyen, A. E., Nabeta, G., Bienfait, S., Schlafstein, A. J., Yu, D. S., & Daddacha, W. (2018). EGFR role in cancer: A potential therapeutic target. In Role of Tyrosine Kinases in Gastrointestinal Malignancies (pp. 225-234). Springer Singapore. https://doi.org/10.1007/978-981-13-1486-5_15