EGFR role in cancer: A potential therapeutic target

Allyson E. Koyen; Geraldine Nabeta; Stevin Bienfait; Ashley J. Schlafstein; David S. Yu; Waaqo Daddacha

doi:10.1007/978-981-13-1486-5_15

EGFR role in cancer: A potential therapeutic target

Allyson E. Koyen, Geraldine Nabeta, Stevin Bienfait, Ashley J. Schlafstein, David S. Yu, Waaqo Daddacha

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Protein kinases play a vital role in the regulation of pathways that control cell growth, proliferation, survival, and differentiation. Epidermal growth factor receptor (EGFR) is a key protein kinase that when dysregulated, disrupts these pathways and, accordingly, is associated with several cancers. Thus, EGFR has been a focus of investigation as a therapeutic target for cancer treatment for the past several decades, with fair success. Despite this success, EGFR-targeted therapies are not universally effective across cancers, and improving the specificity and efficiency of EGFR-targeted therapies is an area of continued investigation. This chapter discusses recent progress made in understanding the role of EGFR in cancer and how the knowledge have been used to develop more precise EGFR-based therapeutic regimens for cancer patients.

Original language	English (US)
Title of host publication	Role of Tyrosine Kinases in Gastrointestinal Malignancies
Publisher	Springer Singapore
Pages	225-234
Number of pages	10
ISBN (Electronic)	9789811314865
ISBN (Print)	9789811314858
DOIs	https://doi.org/10.1007/978-981-13-1486-5_15
State	Published - Jan 1 2018
Externally published	Yes

Keywords

Cancer
EGFR
Protein kinases
Receptors
Therapy

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-981-13-1486-5_15

Cite this

@inbook{1be0c7ad5ac74022840abf17e7506dd3,

title = "EGFR role in cancer: A potential therapeutic target",

abstract = "Protein kinases play a vital role in the regulation of pathways that control cell growth, proliferation, survival, and differentiation. Epidermal growth factor receptor (EGFR) is a key protein kinase that when dysregulated, disrupts these pathways and, accordingly, is associated with several cancers. Thus, EGFR has been a focus of investigation as a therapeutic target for cancer treatment for the past several decades, with fair success. Despite this success, EGFR-targeted therapies are not universally effective across cancers, and improving the specificity and efficiency of EGFR-targeted therapies is an area of continued investigation. This chapter discusses recent progress made in understanding the role of EGFR in cancer and how the knowledge have been used to develop more precise EGFR-based therapeutic regimens for cancer patients.",

keywords = "Cancer, EGFR, Protein kinases, Receptors, Therapy",

author = "Koyen, {Allyson E.} and Geraldine Nabeta and Stevin Bienfait and Schlafstein, {Ashley J.} and Yu, {David S.} and Waaqo Daddacha",

year = "2018",

month = jan,

day = "1",

doi = "10.1007/978-981-13-1486-5_15",

language = "English (US)",

isbn = "9789811314858",

pages = "225--234",

booktitle = "Role of Tyrosine Kinases in Gastrointestinal Malignancies",

publisher = "Springer Singapore",

address = "Singapore",

}

TY - CHAP

T1 - EGFR role in cancer

T2 - A potential therapeutic target

AU - Koyen, Allyson E.

AU - Nabeta, Geraldine

AU - Bienfait, Stevin

AU - Schlafstein, Ashley J.

AU - Yu, David S.

AU - Daddacha, Waaqo

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Protein kinases play a vital role in the regulation of pathways that control cell growth, proliferation, survival, and differentiation. Epidermal growth factor receptor (EGFR) is a key protein kinase that when dysregulated, disrupts these pathways and, accordingly, is associated with several cancers. Thus, EGFR has been a focus of investigation as a therapeutic target for cancer treatment for the past several decades, with fair success. Despite this success, EGFR-targeted therapies are not universally effective across cancers, and improving the specificity and efficiency of EGFR-targeted therapies is an area of continued investigation. This chapter discusses recent progress made in understanding the role of EGFR in cancer and how the knowledge have been used to develop more precise EGFR-based therapeutic regimens for cancer patients.

AB - Protein kinases play a vital role in the regulation of pathways that control cell growth, proliferation, survival, and differentiation. Epidermal growth factor receptor (EGFR) is a key protein kinase that when dysregulated, disrupts these pathways and, accordingly, is associated with several cancers. Thus, EGFR has been a focus of investigation as a therapeutic target for cancer treatment for the past several decades, with fair success. Despite this success, EGFR-targeted therapies are not universally effective across cancers, and improving the specificity and efficiency of EGFR-targeted therapies is an area of continued investigation. This chapter discusses recent progress made in understanding the role of EGFR in cancer and how the knowledge have been used to develop more precise EGFR-based therapeutic regimens for cancer patients.

KW - Cancer

KW - EGFR

KW - Protein kinases

KW - Receptors

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=85063420894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063420894&partnerID=8YFLogxK

U2 - 10.1007/978-981-13-1486-5_15

DO - 10.1007/978-981-13-1486-5_15

M3 - Chapter

AN - SCOPUS:85063420894

SN - 9789811314858

SP - 225

EP - 234

BT - Role of Tyrosine Kinases in Gastrointestinal Malignancies

PB - Springer Singapore

ER -

EGFR role in cancer: A potential therapeutic target

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this