Electrical stimulation of the human hippocampus produces verbal intrusions during memory testing

Gregory P. Lee; David W. Loring; Herman F. Flanigin; Joseph R. Smith; Kimford J. Meador

doi:10.1016/0028-3932(88)90118-2

Electrical stimulation of the human hippocampus produces verbal intrusions during memory testing

Gregory P. Lee, David W. Loring, Herman F. Flanigin, Joseph R. Smith, Kimford J. Meador

Occupational Therapy

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Verbal memory testing was conducted during electrical stimulation of the human hippocampus in 12 epilepsy surgery candidates with unilateral temporal lobe seizure onset. Performance was assessed during baseline, left hippocampal stimulation and right hippocampal stimulation. Verbal intrusion errors were greater during electrical stimulation of the hippocampus contralateral to the seizure focus. These findings suggest that verbal intrusions are related to memory deficits, and that patients with cerebral disease who intrude words from an earlier portion of a learning test are likely to have bilateral cerebral dysfunction.

Original language	English (US)
Pages (from-to)	623-627
Number of pages	5
Journal	Neuropsychologia
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/0028-3932(88)90118-2
State	Published - 1988

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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10.1016/0028-3932(88)90118-2

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title = "Electrical stimulation of the human hippocampus produces verbal intrusions during memory testing",

abstract = "Verbal memory testing was conducted during electrical stimulation of the human hippocampus in 12 epilepsy surgery candidates with unilateral temporal lobe seizure onset. Performance was assessed during baseline, left hippocampal stimulation and right hippocampal stimulation. Verbal intrusion errors were greater during electrical stimulation of the hippocampus contralateral to the seizure focus. These findings suggest that verbal intrusions are related to memory deficits, and that patients with cerebral disease who intrude words from an earlier portion of a learning test are likely to have bilateral cerebral dysfunction.",

author = "Lee, {Gregory P.} and Loring, {David W.} and Flanigin, {Herman F.} and Smith, {Joseph R.} and Meador, {Kimford J.}",

note = "Funding Information: Acknowledgemenr--This work Grants program and NIH/NIA was supported, in part, by the Medical College of Georgia Clinical Investigator Award # K08 AG0034.",

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AU - Lee, Gregory P.

AU - Loring, David W.

AU - Flanigin, Herman F.

AU - Smith, Joseph R.

AU - Meador, Kimford J.

N1 - Funding Information: Acknowledgemenr--This work Grants program and NIH/NIA was supported, in part, by the Medical College of Georgia Clinical Investigator Award # K08 AG0034.

PY - 1988

Y1 - 1988

N2 - Verbal memory testing was conducted during electrical stimulation of the human hippocampus in 12 epilepsy surgery candidates with unilateral temporal lobe seizure onset. Performance was assessed during baseline, left hippocampal stimulation and right hippocampal stimulation. Verbal intrusion errors were greater during electrical stimulation of the hippocampus contralateral to the seizure focus. These findings suggest that verbal intrusions are related to memory deficits, and that patients with cerebral disease who intrude words from an earlier portion of a learning test are likely to have bilateral cerebral dysfunction.

AB - Verbal memory testing was conducted during electrical stimulation of the human hippocampus in 12 epilepsy surgery candidates with unilateral temporal lobe seizure onset. Performance was assessed during baseline, left hippocampal stimulation and right hippocampal stimulation. Verbal intrusion errors were greater during electrical stimulation of the hippocampus contralateral to the seizure focus. These findings suggest that verbal intrusions are related to memory deficits, and that patients with cerebral disease who intrude words from an earlier portion of a learning test are likely to have bilateral cerebral dysfunction.

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Electrical stimulation of the human hippocampus produces verbal intrusions during memory testing

Abstract

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