Electrospun gelatin–arabinoxylan ferulate composite fibers for diabetic chronic wound dressing application

Donald C. Aduba, Seon Sook An, Gretchen S. Selders, W. Andrew Yeudall, Gary L. Bowlin, Todd Kitten, Hu Yang

Research output: Contribution to journalArticle

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Abstract

Blends of arabinoxylan ferulate (AXF) and gelatin (GEL) at 1:1, 2:1 and 4:1 mass ratios were electrospun into composite fibrous mats as a wound-healing drug delivery platform. The composite fibers were characterized in terms of morphology, tensile properties, pore size, porosity and molecular composition. The composite fibers showed excellent cytocompatibility. Silver was impregnated into GEL-AXF nanofibers, and it was slowly released, resulting in bacterial growth inhibition as confirmed by the Kirby–Bauer disk-diffusion assay. This work establishes an electrospun arabinoxylan fibrous material platform with the potential to treat chronic diabetic wounds.

Original languageEnglish (US)
Pages (from-to)660-668
Number of pages9
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume68
Issue number11
DOIs
Publication statusPublished - Jul 24 2019

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Keywords

  • Arabinoxylan
  • chronic wound
  • diabetes
  • electrospinning
  • gelatin
  • nanofiber
  • wound dressing

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemical Engineering(all)
  • Polymers and Plastics

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