Elevated cytokine levels in synovial fluid of rheumatoid arthritis correlates with the presence of cytomegalovirus genome

T. Murayama, N. Tsuchiya, F. Jisaki, M. Ozaki, Daitoku Sakamuro, K. Hirai, S. Shimizu, K. Ito, K. Matsushima, T. Furukawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Synovial fluid aspirated from 34 patients with symptomatic rheumatoid arthritis (RA) was evaluated for the presence of human cytomegalovirus (CMV) genomic material using polymerase chain reaction (PCR), and for levels of interleukin 8 (IL-8) and IL-6 using enzyme-linked immunoadsorbence assay. IL-8 and IL-6 levels were significantly higher in CMV DNA-positive RA patients than CMV DNA-negative RA patients and at least 10-fold higher than in both corresponding control groups of patients with osteoarthritis (OA). These findings suggest an association between elevated IL-8 and IL-6 levels and the presence of the CMV genome in RA patients.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalAutoimmunity
Volume17
Issue number4
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Synovial Fluid
Cytomegalovirus
Rheumatoid Arthritis
Genome
Cytokines
Interleukin-8
Interleukin-6
DNA
Osteoarthritis
Polymerase Chain Reaction
Control Groups
Enzymes

Keywords

  • CMV
  • IL-6
  • IL-8
  • RA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Elevated cytokine levels in synovial fluid of rheumatoid arthritis correlates with the presence of cytomegalovirus genome. / Murayama, T.; Tsuchiya, N.; Jisaki, F.; Ozaki, M.; Sakamuro, Daitoku; Hirai, K.; Shimizu, S.; Ito, K.; Matsushima, K.; Furukawa, T.

In: Autoimmunity, Vol. 17, No. 4, 01.01.1994, p. 333-337.

Research output: Contribution to journalArticle

Murayama, T, Tsuchiya, N, Jisaki, F, Ozaki, M, Sakamuro, D, Hirai, K, Shimizu, S, Ito, K, Matsushima, K & Furukawa, T 1994, 'Elevated cytokine levels in synovial fluid of rheumatoid arthritis correlates with the presence of cytomegalovirus genome', Autoimmunity, vol. 17, no. 4, pp. 333-337. https://doi.org/10.3109/08916939409010674
Murayama, T. ; Tsuchiya, N. ; Jisaki, F. ; Ozaki, M. ; Sakamuro, Daitoku ; Hirai, K. ; Shimizu, S. ; Ito, K. ; Matsushima, K. ; Furukawa, T. / Elevated cytokine levels in synovial fluid of rheumatoid arthritis correlates with the presence of cytomegalovirus genome. In: Autoimmunity. 1994 ; Vol. 17, No. 4. pp. 333-337.
@article{e58f890a429e4aab91d04cd546608cad,
title = "Elevated cytokine levels in synovial fluid of rheumatoid arthritis correlates with the presence of cytomegalovirus genome",
abstract = "Synovial fluid aspirated from 34 patients with symptomatic rheumatoid arthritis (RA) was evaluated for the presence of human cytomegalovirus (CMV) genomic material using polymerase chain reaction (PCR), and for levels of interleukin 8 (IL-8) and IL-6 using enzyme-linked immunoadsorbence assay. IL-8 and IL-6 levels were significantly higher in CMV DNA-positive RA patients than CMV DNA-negative RA patients and at least 10-fold higher than in both corresponding control groups of patients with osteoarthritis (OA). These findings suggest an association between elevated IL-8 and IL-6 levels and the presence of the CMV genome in RA patients.",
keywords = "CMV, IL-6, IL-8, RA",
author = "T. Murayama and N. Tsuchiya and F. Jisaki and M. Ozaki and Daitoku Sakamuro and K. Hirai and S. Shimizu and K. Ito and K. Matsushima and T. Furukawa",
year = "1994",
month = "1",
day = "1",
doi = "10.3109/08916939409010674",
language = "English (US)",
volume = "17",
pages = "333--337",
journal = "Autoimmunity",
issn = "0891-6934",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Elevated cytokine levels in synovial fluid of rheumatoid arthritis correlates with the presence of cytomegalovirus genome

AU - Murayama, T.

AU - Tsuchiya, N.

AU - Jisaki, F.

AU - Ozaki, M.

AU - Sakamuro, Daitoku

AU - Hirai, K.

AU - Shimizu, S.

AU - Ito, K.

AU - Matsushima, K.

AU - Furukawa, T.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Synovial fluid aspirated from 34 patients with symptomatic rheumatoid arthritis (RA) was evaluated for the presence of human cytomegalovirus (CMV) genomic material using polymerase chain reaction (PCR), and for levels of interleukin 8 (IL-8) and IL-6 using enzyme-linked immunoadsorbence assay. IL-8 and IL-6 levels were significantly higher in CMV DNA-positive RA patients than CMV DNA-negative RA patients and at least 10-fold higher than in both corresponding control groups of patients with osteoarthritis (OA). These findings suggest an association between elevated IL-8 and IL-6 levels and the presence of the CMV genome in RA patients.

AB - Synovial fluid aspirated from 34 patients with symptomatic rheumatoid arthritis (RA) was evaluated for the presence of human cytomegalovirus (CMV) genomic material using polymerase chain reaction (PCR), and for levels of interleukin 8 (IL-8) and IL-6 using enzyme-linked immunoadsorbence assay. IL-8 and IL-6 levels were significantly higher in CMV DNA-positive RA patients than CMV DNA-negative RA patients and at least 10-fold higher than in both corresponding control groups of patients with osteoarthritis (OA). These findings suggest an association between elevated IL-8 and IL-6 levels and the presence of the CMV genome in RA patients.

KW - CMV

KW - IL-6

KW - IL-8

KW - RA

UR - http://www.scopus.com/inward/record.url?scp=0028067314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028067314&partnerID=8YFLogxK

U2 - 10.3109/08916939409010674

DO - 10.3109/08916939409010674

M3 - Article

VL - 17

SP - 333

EP - 337

JO - Autoimmunity

JF - Autoimmunity

SN - 0891-6934

IS - 4

ER -