Elevated cytokine levels in synovial fluid of rheumatoid arthritis correlates with the presence of cytomegalovirus genome

T. Murayama, N. Tsuchiya, F. Jisaki, M. Ozaki, D. Sakamuro, K. Hirai, S. Shimizu, K. Ito, K. Matsushima, T. Furukawa

Research output: Contribution to journalArticle

11 Scopus citations


Synovial fluid aspirated from 34 patients with symptomatic rheumatoid arthritis (RA) was evaluated for the presence of human cytomegalovirus (CMV) genomic material using polymerase chain reaction (PCR), and for levels of interleukin 8 (IL-8) and IL-6 using enzyme-linked immunoadsorbence assay. IL-8 and IL-6 levels were significantly higher in CMV DNA-positive RA patients than CMV DNA-negative RA patients and at least 10-fold higher than in both corresponding control groups of patients with osteoarthritis (OA). These findings suggest an association between elevated IL-8 and IL-6 levels and the presence of the CMV genome in RA patients.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
Issue number4
Publication statusPublished - Jan 1 1994
Externally publishedYes



  • CMV
  • IL-6
  • IL-8
  • RA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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