Elevated endothelin-1 levels are associated with decreased arterial elasticity in hypertensive patients.

Adviye Ergul, Dena Jupin, Maribeth H Johnson, L. Michael Prisant

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Endothelin-1 stimulates collagen synthesis and is increased in hypertension, but its effect on collagen degradation remains unknown. The current study tested the hypothesis that elevated endothelin-1 levels are associated with decreased collagenase activity, markers of collagen degradation, and arterial compliance in hypertensive patients. Normotensive (n = 10) and hypertensive (n = 13) patients who were not on any antihypertensive medication were recruited, and small and large artery elasticity index, systemic vascular resistance, pulse pressure, and blood pressure were determined using blood pressure waveform analysis. Large artery elasticity index and collagen degradation products were decreased whereas endothelin-1, systemic vascular resistance, and pulse pressure were elevated in hypertensive patients. Plasma endothelin-1 was negatively correlated with a cross-linked C-terminal telopeptide of collagen type I, a collagen degradation marker (r = -0.43; p = 0.04), collagenase matrix metalloproteinase-1 (r = -0.48; p = 0.02), and large artery elasticity (r = -0.45; p = 0.03) and positively correlated with pulse pressure (r = 0.68; p = 0.0005). These results suggest that endothelin-1 contributes to decreased arterial compliance in hypertension via inhibition of collagen degradation.

Original languageEnglish (US)
Pages (from-to)549-554
Number of pages6
JournalJournal of clinical hypertension (Greenwich, Conn.)
Volume8
Issue number8
DOIs
StatePublished - Jan 1 2006

Fingerprint

Elasticity
Endothelin-1
Collagen
Blood Pressure
Arteries
Collagenases
Vascular Resistance
Compliance
Hypertension
Matrix Metalloproteinase 1
Collagen Type I
Antihypertensive Agents

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Elevated endothelin-1 levels are associated with decreased arterial elasticity in hypertensive patients. / Ergul, Adviye; Jupin, Dena; Johnson, Maribeth H; Prisant, L. Michael.

In: Journal of clinical hypertension (Greenwich, Conn.), Vol. 8, No. 8, 01.01.2006, p. 549-554.

Research output: Contribution to journalArticle

@article{dbeb71b44483444184158c8fb4444844,
title = "Elevated endothelin-1 levels are associated with decreased arterial elasticity in hypertensive patients.",
abstract = "Endothelin-1 stimulates collagen synthesis and is increased in hypertension, but its effect on collagen degradation remains unknown. The current study tested the hypothesis that elevated endothelin-1 levels are associated with decreased collagenase activity, markers of collagen degradation, and arterial compliance in hypertensive patients. Normotensive (n = 10) and hypertensive (n = 13) patients who were not on any antihypertensive medication were recruited, and small and large artery elasticity index, systemic vascular resistance, pulse pressure, and blood pressure were determined using blood pressure waveform analysis. Large artery elasticity index and collagen degradation products were decreased whereas endothelin-1, systemic vascular resistance, and pulse pressure were elevated in hypertensive patients. Plasma endothelin-1 was negatively correlated with a cross-linked C-terminal telopeptide of collagen type I, a collagen degradation marker (r = -0.43; p = 0.04), collagenase matrix metalloproteinase-1 (r = -0.48; p = 0.02), and large artery elasticity (r = -0.45; p = 0.03) and positively correlated with pulse pressure (r = 0.68; p = 0.0005). These results suggest that endothelin-1 contributes to decreased arterial compliance in hypertension via inhibition of collagen degradation.",
author = "Adviye Ergul and Dena Jupin and Johnson, {Maribeth H} and Prisant, {L. Michael}",
year = "2006",
month = "1",
day = "1",
doi = "10.1111/j.1524-6175.2006.05514.x",
language = "English (US)",
volume = "8",
pages = "549--554",
journal = "Journal of the CardioMetabolic Syndrome",
issn = "1524-6175",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Elevated endothelin-1 levels are associated with decreased arterial elasticity in hypertensive patients.

AU - Ergul, Adviye

AU - Jupin, Dena

AU - Johnson, Maribeth H

AU - Prisant, L. Michael

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Endothelin-1 stimulates collagen synthesis and is increased in hypertension, but its effect on collagen degradation remains unknown. The current study tested the hypothesis that elevated endothelin-1 levels are associated with decreased collagenase activity, markers of collagen degradation, and arterial compliance in hypertensive patients. Normotensive (n = 10) and hypertensive (n = 13) patients who were not on any antihypertensive medication were recruited, and small and large artery elasticity index, systemic vascular resistance, pulse pressure, and blood pressure were determined using blood pressure waveform analysis. Large artery elasticity index and collagen degradation products were decreased whereas endothelin-1, systemic vascular resistance, and pulse pressure were elevated in hypertensive patients. Plasma endothelin-1 was negatively correlated with a cross-linked C-terminal telopeptide of collagen type I, a collagen degradation marker (r = -0.43; p = 0.04), collagenase matrix metalloproteinase-1 (r = -0.48; p = 0.02), and large artery elasticity (r = -0.45; p = 0.03) and positively correlated with pulse pressure (r = 0.68; p = 0.0005). These results suggest that endothelin-1 contributes to decreased arterial compliance in hypertension via inhibition of collagen degradation.

AB - Endothelin-1 stimulates collagen synthesis and is increased in hypertension, but its effect on collagen degradation remains unknown. The current study tested the hypothesis that elevated endothelin-1 levels are associated with decreased collagenase activity, markers of collagen degradation, and arterial compliance in hypertensive patients. Normotensive (n = 10) and hypertensive (n = 13) patients who were not on any antihypertensive medication were recruited, and small and large artery elasticity index, systemic vascular resistance, pulse pressure, and blood pressure were determined using blood pressure waveform analysis. Large artery elasticity index and collagen degradation products were decreased whereas endothelin-1, systemic vascular resistance, and pulse pressure were elevated in hypertensive patients. Plasma endothelin-1 was negatively correlated with a cross-linked C-terminal telopeptide of collagen type I, a collagen degradation marker (r = -0.43; p = 0.04), collagenase matrix metalloproteinase-1 (r = -0.48; p = 0.02), and large artery elasticity (r = -0.45; p = 0.03) and positively correlated with pulse pressure (r = 0.68; p = 0.0005). These results suggest that endothelin-1 contributes to decreased arterial compliance in hypertension via inhibition of collagen degradation.

UR - http://www.scopus.com/inward/record.url?scp=33750934751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750934751&partnerID=8YFLogxK

U2 - 10.1111/j.1524-6175.2006.05514.x

DO - 10.1111/j.1524-6175.2006.05514.x

M3 - Article

C2 - 16896270

AN - SCOPUS:33750934751

VL - 8

SP - 549

EP - 554

JO - Journal of the CardioMetabolic Syndrome

JF - Journal of the CardioMetabolic Syndrome

SN - 1524-6175

IS - 8

ER -