Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma

John Edward Janik; John C. Morris; Stefania Pittaluga; Kristin McDonald; Mark Raffeld; Elaine S. Jaffe; Nicole Grant; Martin Gutierrez; Thomas A. Waldmann; Wyndham H. Wilson

doi:10.1182/blood-2003-11-3922

Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma

John Edward Janik, John C. Morris, Stefania Pittaluga, Kristin McDonald, Mark Raffeld, Elaine S. Jaffe, Nicole Grant, Martin Gutierrez, Thomas A. Waldmann, Wyndham H. Wilson

Pulmonary Disease

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Levels of serum soluble interleukin 2 receptor (sIL-2R) provide a reliable marker of disease activity in patients with hairy cell leukemia and adult T-cell leukemia/ lymphoma. The malignant cells in patients with anaplastic large cell lymphoma (ALCL) express CD30 and are usually positive for expression of CD25. We measured serum sIL-2R and soluble CD30 (sCD30) levels in patients with ALCL treated with EPOCH (etoposide, prednisone, Oncovin, Cytoxan, hydroxydaunorubicin) infusional chemotherapy. Serum sCD30 levels were elevated and decreased in response to therapy as previously reported. Serum sIL-2R levels were elevated in 7 of 9 patients with ALCL and decreased in response to treatment. Baseline serum sIL-2R levels varied but correlated well with serum sCD30 levels (r = 0.97). Patients positive for the anaplastic lymphoma kinase (ALK) gene showed elevated sIL-2R levels, whereas those negative for ALK had normal serum sIL-2R levels and their tumors lacked CD25 expression. Serum sIL-2R levels were elevated in both patients with recurrent disease.

Original language	English (US)
Pages (from-to)	3355-3357
Number of pages	3
Journal	Blood
Volume	104
Issue number	10
DOIs	https://doi.org/10.1182/blood-2003-11-3922
State	Published - Nov 15 2004

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood-2003-11-3922

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title = "Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma",

abstract = "Levels of serum soluble interleukin 2 receptor (sIL-2R) provide a reliable marker of disease activity in patients with hairy cell leukemia and adult T-cell leukemia/ lymphoma. The malignant cells in patients with anaplastic large cell lymphoma (ALCL) express CD30 and are usually positive for expression of CD25. We measured serum sIL-2R and soluble CD30 (sCD30) levels in patients with ALCL treated with EPOCH (etoposide, prednisone, Oncovin, Cytoxan, hydroxydaunorubicin) infusional chemotherapy. Serum sCD30 levels were elevated and decreased in response to therapy as previously reported. Serum sIL-2R levels were elevated in 7 of 9 patients with ALCL and decreased in response to treatment. Baseline serum sIL-2R levels varied but correlated well with serum sCD30 levels (r = 0.97). Patients positive for the anaplastic lymphoma kinase (ALK) gene showed elevated sIL-2R levels, whereas those negative for ALK had normal serum sIL-2R levels and their tumors lacked CD25 expression. Serum sIL-2R levels were elevated in both patients with recurrent disease.",

author = "Janik, {John Edward} and Morris, {John C.} and Stefania Pittaluga and Kristin McDonald and Mark Raffeld and Jaffe, {Elaine S.} and Nicole Grant and Martin Gutierrez and Waldmann, {Thomas A.} and Wilson, {Wyndham H.}",

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T1 - Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma

AU - Janik, John Edward

AU - Morris, John C.

AU - Pittaluga, Stefania

AU - McDonald, Kristin

AU - Raffeld, Mark

AU - Jaffe, Elaine S.

AU - Grant, Nicole

AU - Gutierrez, Martin

AU - Waldmann, Thomas A.

AU - Wilson, Wyndham H.

PY - 2004/11/15

Y1 - 2004/11/15

N2 - Levels of serum soluble interleukin 2 receptor (sIL-2R) provide a reliable marker of disease activity in patients with hairy cell leukemia and adult T-cell leukemia/ lymphoma. The malignant cells in patients with anaplastic large cell lymphoma (ALCL) express CD30 and are usually positive for expression of CD25. We measured serum sIL-2R and soluble CD30 (sCD30) levels in patients with ALCL treated with EPOCH (etoposide, prednisone, Oncovin, Cytoxan, hydroxydaunorubicin) infusional chemotherapy. Serum sCD30 levels were elevated and decreased in response to therapy as previously reported. Serum sIL-2R levels were elevated in 7 of 9 patients with ALCL and decreased in response to treatment. Baseline serum sIL-2R levels varied but correlated well with serum sCD30 levels (r = 0.97). Patients positive for the anaplastic lymphoma kinase (ALK) gene showed elevated sIL-2R levels, whereas those negative for ALK had normal serum sIL-2R levels and their tumors lacked CD25 expression. Serum sIL-2R levels were elevated in both patients with recurrent disease.

AB - Levels of serum soluble interleukin 2 receptor (sIL-2R) provide a reliable marker of disease activity in patients with hairy cell leukemia and adult T-cell leukemia/ lymphoma. The malignant cells in patients with anaplastic large cell lymphoma (ALCL) express CD30 and are usually positive for expression of CD25. We measured serum sIL-2R and soluble CD30 (sCD30) levels in patients with ALCL treated with EPOCH (etoposide, prednisone, Oncovin, Cytoxan, hydroxydaunorubicin) infusional chemotherapy. Serum sCD30 levels were elevated and decreased in response to therapy as previously reported. Serum sIL-2R levels were elevated in 7 of 9 patients with ALCL and decreased in response to treatment. Baseline serum sIL-2R levels varied but correlated well with serum sCD30 levels (r = 0.97). Patients positive for the anaplastic lymphoma kinase (ALK) gene showed elevated sIL-2R levels, whereas those negative for ALK had normal serum sIL-2R levels and their tumors lacked CD25 expression. Serum sIL-2R levels were elevated in both patients with recurrent disease.

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Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma

Abstract

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