Embryopathic effects of mercuric salts

Thomas F Gale, Vergil H. Ferm

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Various doses of mercuric acetate and phenylmercuric acetate were administered intravenously to anesthetized pregnant golden hamsters early on the eighth day of gestation in order to study their potential teratogenicity in this species. Fetuses removed from the females on either the twelfth or fourteenth day of gestation exhibited a delayed growth rate and varying degrees of a dorsally localized subcutaneous edema. All doses of mercuric acetate and the three larger doses of phenylmercuric acetate also induced resorption rates significantly higher than the control level of 4%. A small number of miscellaneous abnormalities including: exencephaly, encephalocele, anophthalmia, microphthalmia, cleft lip and palate, rib fusions and syndactylia were also observed in the fetuses from the treated females. Both mercurials also produced the following manifestations of toxicity in the maternal system: weight loss, kidney lesions, diarrhea, slight tremor and somnolence.

Original languageEnglish (US)
Pages (from-to)1341-1347
Number of pages7
JournalLife sciences
Volume10
Issue number23 PART 2
DOIs
StatePublished - Dec 8 1971
Externally publishedYes

Fingerprint

Phenylmercuric Acetate
Fetus
Salts
Anophthalmos
Microphthalmos
Syndactyly
Encephalocele
Pregnancy
Neural Tube Defects
Cleft Lip
Level control
Mesocricetus
Cleft Palate
Tremor
Ribs
Toxicity
Weight Loss
Diarrhea
Edema
Fusion reactions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Embryopathic effects of mercuric salts. / Gale, Thomas F; Ferm, Vergil H.

In: Life sciences, Vol. 10, No. 23 PART 2, 08.12.1971, p. 1341-1347.

Research output: Contribution to journalArticle

Gale, Thomas F ; Ferm, Vergil H. / Embryopathic effects of mercuric salts. In: Life sciences. 1971 ; Vol. 10, No. 23 PART 2. pp. 1341-1347.
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