TY - JOUR
T1 - Embryotoxic effects of chromium trioxide in hamsters
AU - Gale, Thomas F.
N1 - Funding Information:
by USPHS Grant ES00697. I am grateful Janice Reese for typing the manuscript.
PY - 1978
Y1 - 1978
N2 - Chromium trioxide was administered iv at 5, 7.5, 10, and 15 mg/kg to pregnant golden hamsters early on the 8th gestation day. Fetuses were collected from the treated females on the 12th, 14th, and 15th gestation days and examined for the frequency and types of external, internal, and skeletal malformations. It is concluded that exposure of hamsters to this chemical form of a ubiquitous metallic element can kill fetuses in utero and produce edema and retardation as well as specific malformations in surviving fetuses. The most interesting malformations included cleft palate and defects in the ossification of the skeletal system. The results are discussed in relation to other teratogenic agents with particular emphasis on mechanisms of cleft palate formation.
AB - Chromium trioxide was administered iv at 5, 7.5, 10, and 15 mg/kg to pregnant golden hamsters early on the 8th gestation day. Fetuses were collected from the treated females on the 12th, 14th, and 15th gestation days and examined for the frequency and types of external, internal, and skeletal malformations. It is concluded that exposure of hamsters to this chemical form of a ubiquitous metallic element can kill fetuses in utero and produce edema and retardation as well as specific malformations in surviving fetuses. The most interesting malformations included cleft palate and defects in the ossification of the skeletal system. The results are discussed in relation to other teratogenic agents with particular emphasis on mechanisms of cleft palate formation.
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U2 - 10.1016/0013-9351(78)90147-0
DO - 10.1016/0013-9351(78)90147-0
M3 - Article
C2 - 679908
AN - SCOPUS:0018193415
SN - 0013-9351
VL - 16
SP - 101
EP - 109
JO - Environmental Research
JF - Environmental Research
IS - 1-3
ER -