Embryotoxic effects of chromium trioxide in hamsters

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Chromium trioxide was administered iv at 5, 7.5, 10, and 15 mg/kg to pregnant golden hamsters early on the 8th gestation day. Fetuses were collected from the treated females on the 12th, 14th, and 15th gestation days and examined for the frequency and types of external, internal, and skeletal malformations. It is concluded that exposure of hamsters to this chemical form of a ubiquitous metallic element can kill fetuses in utero and produce edema and retardation as well as specific malformations in surviving fetuses. The most interesting malformations included cleft palate and defects in the ossification of the skeletal system. The results are discussed in relation to other teratogenic agents with particular emphasis on mechanisms of cleft palate formation.

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalEnvironmental Research
Volume16
Issue number1-3
DOIs
StatePublished - Jan 1 1978

Fingerprint

Cricetinae
chromium
Fetus
Cleft Palate
pregnancy
Defects
Pregnancy
Mesocricetus
Osteogenesis
defect
Edema
chromium trioxide
malformation
effect
chemical
exposure

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Embryotoxic effects of chromium trioxide in hamsters. / Gale, Thomas F.

In: Environmental Research, Vol. 16, No. 1-3, 01.01.1978, p. 101-109.

Research output: Contribution to journalArticle

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