Emerging role for TNF-α in erectile dysfunction

Fernando S. Carneiro, R Clinton Webb, Rita C. Tostes

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Introduction. A role for cytokines in the pathophysiology of erectile dysfunction (ED) has emerged. Cytokines induce genes that synthesize other peptides in the cytokine family and several mediators, such as prostanoids, leukotrienes, nitric oxide, bradykinin, reactive oxygen species, and platelet-activating factor, all of which can affect vascular function. Consistent with the fact that the cavernosal tissue is a complex extension of the vasculature, risk factors that affect the vasculature have been shown to affect cavernosal function as well. Accordingly, the penile tissue has been recognized as an early sentinel for atherosclerosis that underlies coronary artery disease and cardiovascular diseases (CVD).Aim. To review the literature pertaining to the role of tumor necrosis factor-alpha (TNF-α) in ED.Methods. PubMed search for pertinent publications on the role of cytokines, particularly TNF-α, in CVD and ED.Main Outcome Measures. Clinical and experimental evidence demonstrates that TNF-α may play a role in ED.Results. TNF-α has been shown to play an important role in CVD, mainly due to its direct effects on the vasculature. In addition, high levels of TNF-α were demonstrated in patients with ED. In this review, we present a short description of the physiology of erection and the cytokine network. We focus on vascular actions of TNF-α that support a role for this cytokine as a potential candidate in the pathophysiology of ED, particularly in the context of CVD. A brief overview of its discovery, mechanisms of synthesis, receptors, and its main actions on the systemic and penile vasculature is also presented.Conclusions. Considering that ED results from a systemic arterial defect not only confined to the penile vasculature, implication of TNF-α in the pathophysiology of ED offers a humoral linking between CVD and ED.

Original languageEnglish (US)
Pages (from-to)3823-3834
Number of pages12
JournalJournal of Sexual Medicine
Volume7
Issue number12
DOIs
StatePublished - Jan 1 2010

Fingerprint

Erectile Dysfunction
Tumor Necrosis Factor-alpha
Cytokines
Cardiovascular Diseases
Blood Vessels
Leukotrienes
Platelet Activating Factor
Bradykinin
PubMed
Prostaglandins
Publications
Coronary Artery Disease
Reactive Oxygen Species
Atherosclerosis
Nitric Oxide
Outcome Assessment (Health Care)
Peptides

Keywords

  • Cardiovascular Disease
  • Coronary Artery Disease
  • Cytokines
  • Erectile Dysfunction
  • TNF-α

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Urology

Cite this

Emerging role for TNF-α in erectile dysfunction. / Carneiro, Fernando S.; Webb, R Clinton; Tostes, Rita C.

In: Journal of Sexual Medicine, Vol. 7, No. 12, 01.01.2010, p. 3823-3834.

Research output: Contribution to journalReview article

Carneiro, Fernando S. ; Webb, R Clinton ; Tostes, Rita C. / Emerging role for TNF-α in erectile dysfunction. In: Journal of Sexual Medicine. 2010 ; Vol. 7, No. 12. pp. 3823-3834.
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AB - Introduction. A role for cytokines in the pathophysiology of erectile dysfunction (ED) has emerged. Cytokines induce genes that synthesize other peptides in the cytokine family and several mediators, such as prostanoids, leukotrienes, nitric oxide, bradykinin, reactive oxygen species, and platelet-activating factor, all of which can affect vascular function. Consistent with the fact that the cavernosal tissue is a complex extension of the vasculature, risk factors that affect the vasculature have been shown to affect cavernosal function as well. Accordingly, the penile tissue has been recognized as an early sentinel for atherosclerosis that underlies coronary artery disease and cardiovascular diseases (CVD).Aim. To review the literature pertaining to the role of tumor necrosis factor-alpha (TNF-α) in ED.Methods. PubMed search for pertinent publications on the role of cytokines, particularly TNF-α, in CVD and ED.Main Outcome Measures. Clinical and experimental evidence demonstrates that TNF-α may play a role in ED.Results. TNF-α has been shown to play an important role in CVD, mainly due to its direct effects on the vasculature. In addition, high levels of TNF-α were demonstrated in patients with ED. In this review, we present a short description of the physiology of erection and the cytokine network. We focus on vascular actions of TNF-α that support a role for this cytokine as a potential candidate in the pathophysiology of ED, particularly in the context of CVD. A brief overview of its discovery, mechanisms of synthesis, receptors, and its main actions on the systemic and penile vasculature is also presented.Conclusions. Considering that ED results from a systemic arterial defect not only confined to the penile vasculature, implication of TNF-α in the pathophysiology of ED offers a humoral linking between CVD and ED.

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