@article{a6e7fb5d42644a3892d7032bfdc1278c,
title = "Emerging role of autophagy in kidney function, diseases and aging",
abstract = "Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.",
keywords = "Acute kidney injury, Aging, Autophagy, Glomerulus, Kidney, Kidney transplantation, Podocyte, Polycystic kidney disease, mTOR",
author = "Huber, {Tobias B.} and Edelstein, {Charles L.} and Bj{\"o}rn Hartleben and Ken Inoki and Man Jiang and Daisuke Koya and Shinji Kume and Wilfred Lieberthal and Nicolas Pallet and Alejandro Quiroga and Kameswaran Ravichandran and Katalin Susztak and Sei Yoshida and Zheng Dong",
note = "Funding Information: We thank members of our laboratories for critical reading of the manuscript. This work was supported in part by Deutsche Forschungsgemeinschaft grant KFO 201 (to T.B.H.), by the Excellence Initiative of the German Federal and State Governments EXC 294 (to T.B.H.), by GerontosysII—NephAge (031589GA) (to T.B.H.), by the U.S.National Institutes of Health (RO1DK056851 and DK074835 to C.E., DK058831 and DK087843 to Z.D., DK083491 to K.I.), by the U.S. Veterans Administration (to Z.D. and to W.L.), by Grant-in-Aid For Diabetic Nephropathy Research from the Ministry of Health, Labour and Welfare of Japan (to D.K.), and the KAKENHI 21591148 (to D.K.) and 00452235 (to S.K.).",
year = "2012",
month = jul,
doi = "10.4161/auto.19821",
language = "English (US)",
volume = "8",
pages = "1009--1031",
journal = "Autophagy",
issn = "1554-8627",
publisher = "Landes Bioscience",
number = "7",
}