Emerging role of autophagy in kidney function, diseases and aging

Tobias B. Huber, Charles L. Edelstein, Björn Hartleben, Ken Inoki, Man Jiang Livingston, Daisuke Koya, Shinji Kume, Wilfred Lieberthal, Nicolas Pallet, Alejandro Quiroga, Kameswaran Ravichandran, Katalin Susztak, Sei Yoshida, Zheng Dong

Research output: Contribution to journalReview article

137 Citations (Scopus)

Abstract

Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.

Original languageEnglish (US)
Pages (from-to)1009-1031
Number of pages23
JournalAutophagy
Volume8
Issue number7
DOIs
StatePublished - Jan 1 2012

Fingerprint

Autophagy
Kidney Diseases
Kidney
Poisons
Organelles
Epithelial Cells
Maintenance
Proteins

Keywords

  • Acute kidney injury
  • Aging
  • Autophagy
  • Glomerulus
  • Kidney
  • Kidney transplantation
  • Podocyte
  • Polycystic kidney disease
  • mTOR

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Huber, T. B., Edelstein, C. L., Hartleben, B., Inoki, K., Livingston, M. J., Koya, D., ... Dong, Z. (2012). Emerging role of autophagy in kidney function, diseases and aging. Autophagy, 8(7), 1009-1031. https://doi.org/10.4161/auto.19821

Emerging role of autophagy in kidney function, diseases and aging. / Huber, Tobias B.; Edelstein, Charles L.; Hartleben, Björn; Inoki, Ken; Livingston, Man Jiang; Koya, Daisuke; Kume, Shinji; Lieberthal, Wilfred; Pallet, Nicolas; Quiroga, Alejandro; Ravichandran, Kameswaran; Susztak, Katalin; Yoshida, Sei; Dong, Zheng.

In: Autophagy, Vol. 8, No. 7, 01.01.2012, p. 1009-1031.

Research output: Contribution to journalReview article

Huber, TB, Edelstein, CL, Hartleben, B, Inoki, K, Livingston, MJ, Koya, D, Kume, S, Lieberthal, W, Pallet, N, Quiroga, A, Ravichandran, K, Susztak, K, Yoshida, S & Dong, Z 2012, 'Emerging role of autophagy in kidney function, diseases and aging', Autophagy, vol. 8, no. 7, pp. 1009-1031. https://doi.org/10.4161/auto.19821
Huber TB, Edelstein CL, Hartleben B, Inoki K, Livingston MJ, Koya D et al. Emerging role of autophagy in kidney function, diseases and aging. Autophagy. 2012 Jan 1;8(7):1009-1031. https://doi.org/10.4161/auto.19821
Huber, Tobias B. ; Edelstein, Charles L. ; Hartleben, Björn ; Inoki, Ken ; Livingston, Man Jiang ; Koya, Daisuke ; Kume, Shinji ; Lieberthal, Wilfred ; Pallet, Nicolas ; Quiroga, Alejandro ; Ravichandran, Kameswaran ; Susztak, Katalin ; Yoshida, Sei ; Dong, Zheng. / Emerging role of autophagy in kidney function, diseases and aging. In: Autophagy. 2012 ; Vol. 8, No. 7. pp. 1009-1031.
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