Emerging roles of ALK in immunity and insights for immunotherapy

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises. Here, we provide a timely review on the most updated laboratory and patient-related findings on ALK and immunity, which would grant us important insights for the development of novel ALK immunotherapies for ALK-altered cancers.

Original languageEnglish (US)
Article number426
JournalCancers
Volume12
Issue number2
DOIs
StatePublished - Feb 2020
Externally publishedYes

Keywords

  • ALK-related immunotherapies
  • ALK-wildtype and aberrations in immunity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Emerging roles of ALK in immunity and insights for immunotherapy'. Together they form a unique fingerprint.

Cite this