Emerging roles of ATF3 in the suppression of prostate cancer

Ziyan Wang, Chunhong Yan

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Stress response mediator activating transcription factor 3 (ATF3) engages in diverse oncogenic pathways including the androgen receptor signaling essential for prostatic proliferation. In line with frequent downregulation of ATF3 expression in human prostate cancers, we have provided the first genetic evidence supporting the role of ATF3 as a tumor suppressor in a subset of prostate cancers with PTEN dysfunction.

Original languageEnglish (US)
Article numbere1010948
JournalMolecular and Cellular Oncology
Volume3
Issue number1
DOIs
StatePublished - Jan 2 2016

Keywords

  • ATF3
  • PTEN
  • akt
  • prostate cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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