Enalapril and lisinopril in the treatment of mild to moderate essential hypertension

C. H. Espinel, J. L. Williams, Steven Scott Coughlin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Hypertensive patients were randomly assigned to receive 5 mg of enalapril (n = 50) or 10 mg of lisinopril (n = 47) daily. During a four-week titration period, the doses were increased weekly to a maximum of 40 mg once daily until the treatment goal of diastolic blood pressure (BP) of < 90 mmHg was reached; treatment was then continued for four weeks. Systolic and diastolic BP declined significantly in the two treatment groups, from 147/98 mmHg in both the enalapril and lisinopril groups to 126/82 and 122/81 mmHg, respectively, at the end of treatment. During the first week of treatment, the goal of diastolic BP of < 90 mmHg was reached by 40% of the enalapril group and 62% of the lisinopril group; by the end of the titration period, 98% and 96%, respectively, had achieved the BP goal. Few side effects were reported and there were no abnormal laboratory findings during treatment. It is concluded that once-daily administration of enalapril or lisinopril was generally effective and well-tolerated in the management of mild to moderate uncomplicated essential hypertension.

Original languageEnglish (US)
Pages (from-to)181-190
Number of pages10
JournalClinical Therapeutics
Volume12
Issue number2
StatePublished - Jun 12 1990
Externally publishedYes

Fingerprint

Lisinopril
Enalapril
Blood Pressure
Therapeutics
Essential Hypertension

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Enalapril and lisinopril in the treatment of mild to moderate essential hypertension. / Espinel, C. H.; Williams, J. L.; Coughlin, Steven Scott.

In: Clinical Therapeutics, Vol. 12, No. 2, 12.06.1990, p. 181-190.

Research output: Contribution to journalArticle

@article{a7e187ed0d304eb0b95cac6cde680d7c,
title = "Enalapril and lisinopril in the treatment of mild to moderate essential hypertension",
abstract = "Hypertensive patients were randomly assigned to receive 5 mg of enalapril (n = 50) or 10 mg of lisinopril (n = 47) daily. During a four-week titration period, the doses were increased weekly to a maximum of 40 mg once daily until the treatment goal of diastolic blood pressure (BP) of < 90 mmHg was reached; treatment was then continued for four weeks. Systolic and diastolic BP declined significantly in the two treatment groups, from 147/98 mmHg in both the enalapril and lisinopril groups to 126/82 and 122/81 mmHg, respectively, at the end of treatment. During the first week of treatment, the goal of diastolic BP of < 90 mmHg was reached by 40{\%} of the enalapril group and 62{\%} of the lisinopril group; by the end of the titration period, 98{\%} and 96{\%}, respectively, had achieved the BP goal. Few side effects were reported and there were no abnormal laboratory findings during treatment. It is concluded that once-daily administration of enalapril or lisinopril was generally effective and well-tolerated in the management of mild to moderate uncomplicated essential hypertension.",
author = "Espinel, {C. H.} and Williams, {J. L.} and Coughlin, {Steven Scott}",
year = "1990",
month = "6",
day = "12",
language = "English (US)",
volume = "12",
pages = "181--190",
journal = "Clinical Therapeutics",
issn = "0149-2918",
publisher = "Excerpta Medica",
number = "2",

}

TY - JOUR

T1 - Enalapril and lisinopril in the treatment of mild to moderate essential hypertension

AU - Espinel, C. H.

AU - Williams, J. L.

AU - Coughlin, Steven Scott

PY - 1990/6/12

Y1 - 1990/6/12

N2 - Hypertensive patients were randomly assigned to receive 5 mg of enalapril (n = 50) or 10 mg of lisinopril (n = 47) daily. During a four-week titration period, the doses were increased weekly to a maximum of 40 mg once daily until the treatment goal of diastolic blood pressure (BP) of < 90 mmHg was reached; treatment was then continued for four weeks. Systolic and diastolic BP declined significantly in the two treatment groups, from 147/98 mmHg in both the enalapril and lisinopril groups to 126/82 and 122/81 mmHg, respectively, at the end of treatment. During the first week of treatment, the goal of diastolic BP of < 90 mmHg was reached by 40% of the enalapril group and 62% of the lisinopril group; by the end of the titration period, 98% and 96%, respectively, had achieved the BP goal. Few side effects were reported and there were no abnormal laboratory findings during treatment. It is concluded that once-daily administration of enalapril or lisinopril was generally effective and well-tolerated in the management of mild to moderate uncomplicated essential hypertension.

AB - Hypertensive patients were randomly assigned to receive 5 mg of enalapril (n = 50) or 10 mg of lisinopril (n = 47) daily. During a four-week titration period, the doses were increased weekly to a maximum of 40 mg once daily until the treatment goal of diastolic blood pressure (BP) of < 90 mmHg was reached; treatment was then continued for four weeks. Systolic and diastolic BP declined significantly in the two treatment groups, from 147/98 mmHg in both the enalapril and lisinopril groups to 126/82 and 122/81 mmHg, respectively, at the end of treatment. During the first week of treatment, the goal of diastolic BP of < 90 mmHg was reached by 40% of the enalapril group and 62% of the lisinopril group; by the end of the titration period, 98% and 96%, respectively, had achieved the BP goal. Few side effects were reported and there were no abnormal laboratory findings during treatment. It is concluded that once-daily administration of enalapril or lisinopril was generally effective and well-tolerated in the management of mild to moderate uncomplicated essential hypertension.

UR - http://www.scopus.com/inward/record.url?scp=0025307035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025307035&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 181

EP - 190

JO - Clinical Therapeutics

JF - Clinical Therapeutics

SN - 0149-2918

IS - 2

ER -