Endocrine outcomes of transsphenoidal surgery for pituitary apoplexy versus elective surgery for pituitary adenoma

Paul Marcet, Jason Paluzzi, Anthony Morrison, Fernando Vale Diaz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To determine the rate of hormone replacement therapy (HRT) after transsphenoidal surgery (TSS) for pituitary apoplexy (PA) versus elective resection of a null cell (NC) macroadenoma. Methods: A retrospective cohort study was performed. Data was collected on all consecutive patients who underwent TSS from December 31, 2000 to December 31, 2016. Patients were split into two groups: (1) patients that presented with PA, and (2) patients that underwent elective TSS for NC macroadenoma. Postoperative pituitary function was determined by examining HRT, hormone lab values, and an evaluation by an endocrinologist for each patient. The odds ratio (OR) was calculated to determine if there was an association between PA and the need for HRT after surgery when compared to elective resection of a NC macroadenoma. Results: The need for HRT was significantly higher following surgery for PA compared to resection of a NC macroadenoma (14.7% versus 2.9%, OR = 5.690; 95% confidence interval (CI) = 1.439 to 22.500; P = .013). Conclusion: There is an increased need for hormone replacement therapy after surgery in patients with PA versus patients undergoing elective resection of a NC macroadenoma. Further studies are warranted to strengthen this data and help determine further predictors of the need for HRT.

Original languageEnglish (US)
Pages (from-to)353-360
Number of pages8
JournalEndocrine Practice
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2019
Externally publishedYes

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Pituitary Apoplexy
Pituitary Neoplasms
Hormone Replacement Therapy
Null Lymphocytes
Odds Ratio
Cohort Studies
Retrospective Studies
Hormones
Confidence Intervals

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Endocrine outcomes of transsphenoidal surgery for pituitary apoplexy versus elective surgery for pituitary adenoma. / Marcet, Paul; Paluzzi, Jason; Morrison, Anthony; Vale Diaz, Fernando.

In: Endocrine Practice, Vol. 25, No. 4, 01.04.2019, p. 353-360.

Research output: Contribution to journalArticle

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