Endocrine studies in the arrhenoblastoma

V. B. Mahesh; P. G. McDonough; C. A. Deleo

doi:10.1016/0002-9378(70)90583-1

Endocrine studies in the arrhenoblastoma

V. B. Mahesh, P. G. McDonough, C. A. Deleo

Physiology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Urinary steroid excretion patterns before and after dexamethasone suppression were studied in a patient with arrhenoblastoma prior to operation, one week, and 5 months after the removal of the tumor. The routine 17-ketosteroid and total fractionated 17-ketosteroid values were elevated. The elevation was primarily in the 11-deoxy-17-ketosteroid fraction, with androsterone and etiocholanolone being prominent contributors. Only the 11-oxygenated 17-ketosteroid and tetrahydrocorticoid fractions were suppressed to undetectable levels with dexamethasone. After the removal of the arrhenoblastoma, all fractionated neutral steroid levels returned to normal limits and were suppressed well with dexamethasone. Studies of peripheral blood obtained prior to and after operation and ovarian vein blood obtained during operation provided evidence of the secretion of dehydroepiandrosterone, Δ⁴-androstenedione, and testosterone by the arrhenoblastoma.

Original language	English (US)
Pages (from-to)	183-187
Number of pages	5
Journal	American journal of obstetrics and gynecology
Volume	107
Issue number	2
DOIs	https://doi.org/10.1016/0002-9378(70)90583-1
State	Published - May 15 1970

ASJC Scopus subject areas

Obstetrics and Gynecology

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@article{b7251744b66844469982894f671ddeb1,

title = "Endocrine studies in the arrhenoblastoma",

abstract = "Urinary steroid excretion patterns before and after dexamethasone suppression were studied in a patient with arrhenoblastoma prior to operation, one week, and 5 months after the removal of the tumor. The routine 17-ketosteroid and total fractionated 17-ketosteroid values were elevated. The elevation was primarily in the 11-deoxy-17-ketosteroid fraction, with androsterone and etiocholanolone being prominent contributors. Only the 11-oxygenated 17-ketosteroid and tetrahydrocorticoid fractions were suppressed to undetectable levels with dexamethasone. After the removal of the arrhenoblastoma, all fractionated neutral steroid levels returned to normal limits and were suppressed well with dexamethasone. Studies of peripheral blood obtained prior to and after operation and ovarian vein blood obtained during operation provided evidence of the secretion of dehydroepiandrosterone, Δ4-androstenedione, and testosterone by the arrhenoblastoma.",

author = "Mahesh, {V. B.} and McDonough, {P. G.} and Deleo, {C. A.}",

note = "Funding Information: This study was supported by Research Grant No. AM 04429-09 from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, United States Public Health Service.",

year = "1970",

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doi = "10.1016/0002-9378(70)90583-1",

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AU - Mahesh, V. B.

AU - McDonough, P. G.

AU - Deleo, C. A.

N1 - Funding Information: This study was supported by Research Grant No. AM 04429-09 from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, United States Public Health Service.

PY - 1970/5/15

Y1 - 1970/5/15

N2 - Urinary steroid excretion patterns before and after dexamethasone suppression were studied in a patient with arrhenoblastoma prior to operation, one week, and 5 months after the removal of the tumor. The routine 17-ketosteroid and total fractionated 17-ketosteroid values were elevated. The elevation was primarily in the 11-deoxy-17-ketosteroid fraction, with androsterone and etiocholanolone being prominent contributors. Only the 11-oxygenated 17-ketosteroid and tetrahydrocorticoid fractions were suppressed to undetectable levels with dexamethasone. After the removal of the arrhenoblastoma, all fractionated neutral steroid levels returned to normal limits and were suppressed well with dexamethasone. Studies of peripheral blood obtained prior to and after operation and ovarian vein blood obtained during operation provided evidence of the secretion of dehydroepiandrosterone, Δ4-androstenedione, and testosterone by the arrhenoblastoma.

AB - Urinary steroid excretion patterns before and after dexamethasone suppression were studied in a patient with arrhenoblastoma prior to operation, one week, and 5 months after the removal of the tumor. The routine 17-ketosteroid and total fractionated 17-ketosteroid values were elevated. The elevation was primarily in the 11-deoxy-17-ketosteroid fraction, with androsterone and etiocholanolone being prominent contributors. Only the 11-oxygenated 17-ketosteroid and tetrahydrocorticoid fractions were suppressed to undetectable levels with dexamethasone. After the removal of the arrhenoblastoma, all fractionated neutral steroid levels returned to normal limits and were suppressed well with dexamethasone. Studies of peripheral blood obtained prior to and after operation and ovarian vein blood obtained during operation provided evidence of the secretion of dehydroepiandrosterone, Δ4-androstenedione, and testosterone by the arrhenoblastoma.

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Endocrine studies in the arrhenoblastoma

Abstract

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