Endocrine studies in the arrhenoblastoma

V. B. Mahesh, P. G. McDonough, C. A. Deleo

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Urinary steroid excretion patterns before and after dexamethasone suppression were studied in a patient with arrhenoblastoma prior to operation, one week, and 5 months after the removal of the tumor. The routine 17-ketosteroid and total fractionated 17-ketosteroid values were elevated. The elevation was primarily in the 11-deoxy-17-ketosteroid fraction, with androsterone and etiocholanolone being prominent contributors. Only the 11-oxygenated 17-ketosteroid and tetrahydrocorticoid fractions were suppressed to undetectable levels with dexamethasone. After the removal of the arrhenoblastoma, all fractionated neutral steroid levels returned to normal limits and were suppressed well with dexamethasone. Studies of peripheral blood obtained prior to and after operation and ovarian vein blood obtained during operation provided evidence of the secretion of dehydroepiandrosterone, Δ4-androstenedione, and testosterone by the arrhenoblastoma.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume107
Issue number2
DOIs
StatePublished - May 15 1970

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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