Abstract
Urinary steroid excretion patterns before and after dexamethasone suppression were studied in a patient with arrhenoblastoma prior to operation, one week, and 5 months after the removal of the tumor. The routine 17-ketosteroid and total fractionated 17-ketosteroid values were elevated. The elevation was primarily in the 11-deoxy-17-ketosteroid fraction, with androsterone and etiocholanolone being prominent contributors. Only the 11-oxygenated 17-ketosteroid and tetrahydrocorticoid fractions were suppressed to undetectable levels with dexamethasone. After the removal of the arrhenoblastoma, all fractionated neutral steroid levels returned to normal limits and were suppressed well with dexamethasone. Studies of peripheral blood obtained prior to and after operation and ovarian vein blood obtained during operation provided evidence of the secretion of dehydroepiandrosterone, Δ4-androstenedione, and testosterone by the arrhenoblastoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 183-187 |
| Number of pages | 5 |
| Journal | American journal of obstetrics and gynecology |
| Volume | 107 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 15 1970 |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Endocrine studies in the arrhenoblastoma. / Mahesh, V. B.; McDonough, P. G.; Deleo, C. A.
In: American journal of obstetrics and gynecology, Vol. 107, No. 2, 15.05.1970, p. 183-187.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Endocrine studies in the arrhenoblastoma
AU - Mahesh, V. B.
AU - McDonough, P. G.
AU - Deleo, C. A.
PY - 1970/5/15
Y1 - 1970/5/15
N2 - Urinary steroid excretion patterns before and after dexamethasone suppression were studied in a patient with arrhenoblastoma prior to operation, one week, and 5 months after the removal of the tumor. The routine 17-ketosteroid and total fractionated 17-ketosteroid values were elevated. The elevation was primarily in the 11-deoxy-17-ketosteroid fraction, with androsterone and etiocholanolone being prominent contributors. Only the 11-oxygenated 17-ketosteroid and tetrahydrocorticoid fractions were suppressed to undetectable levels with dexamethasone. After the removal of the arrhenoblastoma, all fractionated neutral steroid levels returned to normal limits and were suppressed well with dexamethasone. Studies of peripheral blood obtained prior to and after operation and ovarian vein blood obtained during operation provided evidence of the secretion of dehydroepiandrosterone, Δ4-androstenedione, and testosterone by the arrhenoblastoma.
AB - Urinary steroid excretion patterns before and after dexamethasone suppression were studied in a patient with arrhenoblastoma prior to operation, one week, and 5 months after the removal of the tumor. The routine 17-ketosteroid and total fractionated 17-ketosteroid values were elevated. The elevation was primarily in the 11-deoxy-17-ketosteroid fraction, with androsterone and etiocholanolone being prominent contributors. Only the 11-oxygenated 17-ketosteroid and tetrahydrocorticoid fractions were suppressed to undetectable levels with dexamethasone. After the removal of the arrhenoblastoma, all fractionated neutral steroid levels returned to normal limits and were suppressed well with dexamethasone. Studies of peripheral blood obtained prior to and after operation and ovarian vein blood obtained during operation provided evidence of the secretion of dehydroepiandrosterone, Δ4-androstenedione, and testosterone by the arrhenoblastoma.
UR - http://www.scopus.com/inward/record.url?scp=0014947707&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0014947707&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(70)90583-1
DO - 10.1016/0002-9378(70)90583-1
M3 - Article
C2 - 4315088
AN - SCOPUS:0014947707
VL - 107
SP - 183
EP - 187
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 2
ER -