Endogenous excitatory amino acid regulation of the progesterone-induced LH and FSH surge in estrogen-primed ovariectomized rats

Darrell W Brann, V. B. Mahesh

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The role of endogenous excitatory amino acid neurotransmission in the regulation of progesterone and triamcinolone acetonide-induced LH and FSH release was examined. Estrogen-primed ovariectomized rats were utilized in this study. Progesterone or triamcinolone acetonide (1 mg/kg body weight) treatment led to a highly significant elevation of serum LH and FSH levels 5 h later. Treatment with the selective noncompetitive NMDA receptor antagonist, MK801, had no effect on serum LH and FSH levels when compared to estrogen controls. However, MK801 administered 1 h prior to progesterone or triamcinolone acetonide administration completely blocked their ability to induce LH and FSH surges. These studies demonstrate for the first time the involvement of endogenous excitatory amino acid neurotransmission in the mediation of progesterone and corticosteroid-induced LH and FSH surges.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalNeuroendocrinology
Volume53
Issue number1
DOIs
StatePublished - Jan 1 1991

Fingerprint

Excitatory Amino Acids
Triamcinolone Acetonide
Progesterone
Estrogens
Synaptic Transmission
N-Methyl-D-Aspartate Receptors
Serum
Adrenal Cortex Hormones
Body Weight

Keywords

  • corticosteroid
  • follicle-stimulating hormone
  • luteinizing hormone
  • N-methyl-D-aspartate
  • progesterone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Endogenous excitatory amino acid regulation of the progesterone-induced LH and FSH surge in estrogen-primed ovariectomized rats. / Brann, Darrell W; Mahesh, V. B.

In: Neuroendocrinology, Vol. 53, No. 1, 01.01.1991, p. 107-110.

Research output: Contribution to journalArticle

@article{0c78ce49def24fada46ca1bb4956cd5d,
title = "Endogenous excitatory amino acid regulation of the progesterone-induced LH and FSH surge in estrogen-primed ovariectomized rats",
abstract = "The role of endogenous excitatory amino acid neurotransmission in the regulation of progesterone and triamcinolone acetonide-induced LH and FSH release was examined. Estrogen-primed ovariectomized rats were utilized in this study. Progesterone or triamcinolone acetonide (1 mg/kg body weight) treatment led to a highly significant elevation of serum LH and FSH levels 5 h later. Treatment with the selective noncompetitive NMDA receptor antagonist, MK801, had no effect on serum LH and FSH levels when compared to estrogen controls. However, MK801 administered 1 h prior to progesterone or triamcinolone acetonide administration completely blocked their ability to induce LH and FSH surges. These studies demonstrate for the first time the involvement of endogenous excitatory amino acid neurotransmission in the mediation of progesterone and corticosteroid-induced LH and FSH surges.",
keywords = "corticosteroid, follicle-stimulating hormone, luteinizing hormone, N-methyl-D-aspartate, progesterone",
author = "Brann, {Darrell W} and Mahesh, {V. B.}",
year = "1991",
month = "1",
day = "1",
doi = "10.1159/000125706",
language = "English (US)",
volume = "53",
pages = "107--110",
journal = "Neuroendocrinology",
issn = "0028-3835",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Endogenous excitatory amino acid regulation of the progesterone-induced LH and FSH surge in estrogen-primed ovariectomized rats

AU - Brann, Darrell W

AU - Mahesh, V. B.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The role of endogenous excitatory amino acid neurotransmission in the regulation of progesterone and triamcinolone acetonide-induced LH and FSH release was examined. Estrogen-primed ovariectomized rats were utilized in this study. Progesterone or triamcinolone acetonide (1 mg/kg body weight) treatment led to a highly significant elevation of serum LH and FSH levels 5 h later. Treatment with the selective noncompetitive NMDA receptor antagonist, MK801, had no effect on serum LH and FSH levels when compared to estrogen controls. However, MK801 administered 1 h prior to progesterone or triamcinolone acetonide administration completely blocked their ability to induce LH and FSH surges. These studies demonstrate for the first time the involvement of endogenous excitatory amino acid neurotransmission in the mediation of progesterone and corticosteroid-induced LH and FSH surges.

AB - The role of endogenous excitatory amino acid neurotransmission in the regulation of progesterone and triamcinolone acetonide-induced LH and FSH release was examined. Estrogen-primed ovariectomized rats were utilized in this study. Progesterone or triamcinolone acetonide (1 mg/kg body weight) treatment led to a highly significant elevation of serum LH and FSH levels 5 h later. Treatment with the selective noncompetitive NMDA receptor antagonist, MK801, had no effect on serum LH and FSH levels when compared to estrogen controls. However, MK801 administered 1 h prior to progesterone or triamcinolone acetonide administration completely blocked their ability to induce LH and FSH surges. These studies demonstrate for the first time the involvement of endogenous excitatory amino acid neurotransmission in the mediation of progesterone and corticosteroid-induced LH and FSH surges.

KW - corticosteroid

KW - follicle-stimulating hormone

KW - luteinizing hormone

KW - N-methyl-D-aspartate

KW - progesterone

UR - http://www.scopus.com/inward/record.url?scp=0026088643&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026088643&partnerID=8YFLogxK

U2 - 10.1159/000125706

DO - 10.1159/000125706

M3 - Article

C2 - 1828545

AN - SCOPUS:0026088643

VL - 53

SP - 107

EP - 110

JO - Neuroendocrinology

JF - Neuroendocrinology

SN - 0028-3835

IS - 1

ER -