Endometrial thickness is related to miscarriage rate, but not to the estradiol concentration, in cycles down-regulated with gonadotropin-releasing hormone antagonist

Laura Detti, Frank D. Yelian, Michael L. Kruger, Michael P. Diamond, Anuradha Rode, Mohamed F.M. Mitwally, Elizabeth E. Puscheck

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

In this retrospective cohort study of 102 ovarian stimulation cycles for IVF/intracytoplasmic sperm injection using GnRH antagonist and gonadotropins, we sought to assess the effect of high E2 levels on endometrial stripe thickness and its association with pregnancy outcomes and serum E2 levels. We found no significant correlation between serum E2 levels (both peak and area under the curve E2 concentration) and the endometrial thickness. However, there was a statistically significant inverse relationship with early pregnancy loss (31%) if the endometrial thickness was <9.8 mm (sensitivity 71%; specificity 76%).

Original languageEnglish (US)
Pages (from-to)998-1001
Number of pages4
JournalFertility and sterility
Volume89
Issue number4
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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