Endoscopic management of sphenoclival neoplasms: Anatomical correlates and patient outcomes

Clementino Arturo Solares, David Grindler, Amber Luong, Seth J. Kanowitz, Burak Sade, Martin J. Citardi, Pete S. Batra

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To characterize the endoscopic anatomy of the sphenoid sinus and the adjacent clivus and cavernous sinus, and to review patient outcomes for neoplasms in this region. Study Design: Cadaver dissection and chart review. Setting: Cadaver laboratory and tertiary care center. Subjects and Methods: Fresh-frozen cadaver heads were dissected to study the endoscopic anatomy of the sphenoclival region. Retrospective chart review of patients undergoing endoscopic resection of sphenoclival neoplasms between 2000 and 2008 was performed. Results: Transnasal endoscopic access to the sphenoid sinus was obtained in 10 cadaver heads. A clival window with mean dimensions of 1.4 cm × 1.7 cm was created. Through the clival window, identification and dissection of the basilar and vertebral arteries, mamillary bodies, third ventricle, cranial nerves III through VI, and cervical rootlets were possible. Nineteen patients with mean age of 56.2 years were treated. The most common pathologies were inverted papilloma (5), chordoma (4), squamous cell carcinoma (2), and adenoid cystic carcinoma (2). None of the patients required adjunct craniotomies. Nine patients received adjuvant therapies. Thirteen (68.4%) patients had no evidence of disease, five (26.3%) patients were alive with disease, and one (5.3%) patient died of disease at mean follow-up of 32.6 months. Conclusion: The sphenoclival region poses a significant surgical challenge given its central location at the skull base and proximity to critical structures. This study demonstrates that transnasal endoscopic access to the sphenoclival region is technically feasible and allows successful surgical extirpation of tumors with a low complication rate and acceptable patient outcomes.

Original languageEnglish (US)
Pages (from-to)315-321
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Volume142
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Cadaver
Neoplasms
Oculomotor Nerve
Sphenoid Sinus
Dissection
Anatomy
Head
Mammillary Bodies
Inverted Papilloma
Posterior Cranial Fossa
Chordoma
Adenoid Cystic Carcinoma
Cavernous Sinus
Basilar Artery
Third Ventricle
Craniotomy
Skull Base
Tertiary Care Centers
Squamous Cell Carcinoma
Pathology

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Solares, C. A., Grindler, D., Luong, A., Kanowitz, S. J., Sade, B., Citardi, M. J., & Batra, P. S. (2010). Endoscopic management of sphenoclival neoplasms: Anatomical correlates and patient outcomes. Otolaryngology - Head and Neck Surgery, 142(3), 315-321. https://doi.org/10.1016/j.otohns.2009.11.031

Endoscopic management of sphenoclival neoplasms : Anatomical correlates and patient outcomes. / Solares, Clementino Arturo; Grindler, David; Luong, Amber; Kanowitz, Seth J.; Sade, Burak; Citardi, Martin J.; Batra, Pete S.

In: Otolaryngology - Head and Neck Surgery, Vol. 142, No. 3, 01.03.2010, p. 315-321.

Research output: Contribution to journalArticle

Solares, CA, Grindler, D, Luong, A, Kanowitz, SJ, Sade, B, Citardi, MJ & Batra, PS 2010, 'Endoscopic management of sphenoclival neoplasms: Anatomical correlates and patient outcomes', Otolaryngology - Head and Neck Surgery, vol. 142, no. 3, pp. 315-321. https://doi.org/10.1016/j.otohns.2009.11.031
Solares, Clementino Arturo ; Grindler, David ; Luong, Amber ; Kanowitz, Seth J. ; Sade, Burak ; Citardi, Martin J. ; Batra, Pete S. / Endoscopic management of sphenoclival neoplasms : Anatomical correlates and patient outcomes. In: Otolaryngology - Head and Neck Surgery. 2010 ; Vol. 142, No. 3. pp. 315-321.
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