Endothelial progenitor cell biology in disease and tissue regeneration

Andrea L. George, Pradeep Bangalore-Prakash, Shilpi Rajoria, Robert Suriano, Arulkumaran Shanmugam, Abraham Mittelman, Raj K. Tiwari

Research output: Contribution to journalReview article

98 Citations (Scopus)

Abstract

Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marrow niche to sites of inflammation and tumor to induce neovasculogenesis has afforded a novel opportunity to understand the tissue microenvironment and specific cell-cell interactive pathways. This review provides a comprehensive up-to-date understanding of the physiological function and therapeutic utility of these cells. The emphasis is on the systemic factors that modulate their differentiation/mobilization and survival and presents the challenges of its potential therapeutic clinical utility as a diagnostic and prognostic reagent.

Original languageEnglish (US)
Article number24
JournalJournal of Hematology and Oncology
Volume4
DOIs
StatePublished - May 26 2011

Fingerprint

Cell Biology
Regeneration
Cellular Microenvironment
Diabetic Retinopathy
Neoplasms
Ischemia
Bone Marrow
Inflammation
Therapeutics
Endothelial Progenitor Cells

Keywords

  • Cancer
  • Chemokines
  • Cluster of Differentiation Antigens
  • Endothelial Progenitor Cells
  • Estrogen
  • Inflammation
  • Neovascularization
  • Proangiogenic proteins
  • Tumor Microenvironment

ASJC Scopus subject areas

  • Hematology
  • Molecular Biology
  • Oncology
  • Cancer Research

Cite this

George, A. L., Bangalore-Prakash, P., Rajoria, S., Suriano, R., Shanmugam, A., Mittelman, A., & Tiwari, R. K. (2011). Endothelial progenitor cell biology in disease and tissue regeneration. Journal of Hematology and Oncology, 4, [24]. https://doi.org/10.1186/1756-8722-4-24

Endothelial progenitor cell biology in disease and tissue regeneration. / George, Andrea L.; Bangalore-Prakash, Pradeep; Rajoria, Shilpi; Suriano, Robert; Shanmugam, Arulkumaran; Mittelman, Abraham; Tiwari, Raj K.

In: Journal of Hematology and Oncology, Vol. 4, 24, 26.05.2011.

Research output: Contribution to journalReview article

George, AL, Bangalore-Prakash, P, Rajoria, S, Suriano, R, Shanmugam, A, Mittelman, A & Tiwari, RK 2011, 'Endothelial progenitor cell biology in disease and tissue regeneration', Journal of Hematology and Oncology, vol. 4, 24. https://doi.org/10.1186/1756-8722-4-24
George AL, Bangalore-Prakash P, Rajoria S, Suriano R, Shanmugam A, Mittelman A et al. Endothelial progenitor cell biology in disease and tissue regeneration. Journal of Hematology and Oncology. 2011 May 26;4. 24. https://doi.org/10.1186/1756-8722-4-24
George, Andrea L. ; Bangalore-Prakash, Pradeep ; Rajoria, Shilpi ; Suriano, Robert ; Shanmugam, Arulkumaran ; Mittelman, Abraham ; Tiwari, Raj K. / Endothelial progenitor cell biology in disease and tissue regeneration. In: Journal of Hematology and Oncology. 2011 ; Vol. 4.
@article{db4d0b256a314160884d36da9eb7055d,
title = "Endothelial progenitor cell biology in disease and tissue regeneration",
abstract = "Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marrow niche to sites of inflammation and tumor to induce neovasculogenesis has afforded a novel opportunity to understand the tissue microenvironment and specific cell-cell interactive pathways. This review provides a comprehensive up-to-date understanding of the physiological function and therapeutic utility of these cells. The emphasis is on the systemic factors that modulate their differentiation/mobilization and survival and presents the challenges of its potential therapeutic clinical utility as a diagnostic and prognostic reagent.",
keywords = "Cancer, Chemokines, Cluster of Differentiation Antigens, Endothelial Progenitor Cells, Estrogen, Inflammation, Neovascularization, Proangiogenic proteins, Tumor Microenvironment",
author = "George, {Andrea L.} and Pradeep Bangalore-Prakash and Shilpi Rajoria and Robert Suriano and Arulkumaran Shanmugam and Abraham Mittelman and Tiwari, {Raj K.}",
year = "2011",
month = "5",
day = "26",
doi = "10.1186/1756-8722-4-24",
language = "English (US)",
volume = "4",
journal = "Journal of Hematology and Oncology",
issn = "1756-8722",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Endothelial progenitor cell biology in disease and tissue regeneration

AU - George, Andrea L.

AU - Bangalore-Prakash, Pradeep

AU - Rajoria, Shilpi

AU - Suriano, Robert

AU - Shanmugam, Arulkumaran

AU - Mittelman, Abraham

AU - Tiwari, Raj K.

PY - 2011/5/26

Y1 - 2011/5/26

N2 - Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marrow niche to sites of inflammation and tumor to induce neovasculogenesis has afforded a novel opportunity to understand the tissue microenvironment and specific cell-cell interactive pathways. This review provides a comprehensive up-to-date understanding of the physiological function and therapeutic utility of these cells. The emphasis is on the systemic factors that modulate their differentiation/mobilization and survival and presents the challenges of its potential therapeutic clinical utility as a diagnostic and prognostic reagent.

AB - Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marrow niche to sites of inflammation and tumor to induce neovasculogenesis has afforded a novel opportunity to understand the tissue microenvironment and specific cell-cell interactive pathways. This review provides a comprehensive up-to-date understanding of the physiological function and therapeutic utility of these cells. The emphasis is on the systemic factors that modulate their differentiation/mobilization and survival and presents the challenges of its potential therapeutic clinical utility as a diagnostic and prognostic reagent.

KW - Cancer

KW - Chemokines

KW - Cluster of Differentiation Antigens

KW - Endothelial Progenitor Cells

KW - Estrogen

KW - Inflammation

KW - Neovascularization

KW - Proangiogenic proteins

KW - Tumor Microenvironment

UR - http://www.scopus.com/inward/record.url?scp=79956285058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79956285058&partnerID=8YFLogxK

U2 - 10.1186/1756-8722-4-24

DO - 10.1186/1756-8722-4-24

M3 - Review article

C2 - 21609465

AN - SCOPUS:79956285058

VL - 4

JO - Journal of Hematology and Oncology

JF - Journal of Hematology and Oncology

SN - 1756-8722

M1 - 24

ER -