Endothelial progenitor cell biology in disease and tissue regeneration

Andrea L. George, Pradeep Bangalore-Prakash, Shilpi Rajoria, Robert Suriano, Arulkumaran Shanmugam, Abraham Mittelman, Raj K. Tiwari

Research output: Contribution to journalReview articlepeer-review

109 Scopus citations

Abstract

Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marrow niche to sites of inflammation and tumor to induce neovasculogenesis has afforded a novel opportunity to understand the tissue microenvironment and specific cell-cell interactive pathways. This review provides a comprehensive up-to-date understanding of the physiological function and therapeutic utility of these cells. The emphasis is on the systemic factors that modulate their differentiation/mobilization and survival and presents the challenges of its potential therapeutic clinical utility as a diagnostic and prognostic reagent.

Original languageEnglish (US)
Article number24
JournalJournal of Hematology and Oncology
Volume4
DOIs
StatePublished - 2011

Keywords

  • Cancer
  • Chemokines
  • Cluster of Differentiation Antigens
  • Endothelial Progenitor Cells
  • Estrogen
  • Inflammation
  • Neovascularization
  • Proangiogenic proteins
  • Tumor Microenvironment

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Oncology
  • Cancer Research

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