Endothelial progenitor cells=EPC=elemental pernicious complexity

Ralf P. Brandes, Masuko Ushio-Fukai

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Endothelial progenitor cells (EPCs) represent a heterogeneous population of cells with a pro-angiogenic potential that are derived not only from bone marrow but also from other tissues. Depending on the model and cell type used, the pro-angiogenic effect is a consequence of direct vascular integration, the paracrine release of growth factors and cytokines, or complex interactions with other cellular components like monocytes or platelets. The pro-angiogenic potential of EPCs is dependent on the particular type of EPC studied and modulated by the risk and life style factors of the patient as well as by local factors determining the homing to diseased tissue and the EPC proteome. In this Forum on EPCs these aspects will be covered in individual review articles, which are accompanied by two original research studies on the role of NADPH oxidases for EPC mobilization and the impact of organic nitrates on EPCs.

Original languageEnglish (US)
Pages (from-to)911-914
Number of pages4
JournalAntioxidants and Redox Signaling
Volume15
Issue number4
DOIs
StatePublished - Aug 15 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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