Endothelial regulation of coronary microcirculation in health and cardiometabolic diseases

Akos Koller, Marta Balasko, Zsolt Bagi

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Cardiometabolic disorders have been shown to impair coronary microvascular functions leading to diminished cardiac performance and increased mortality. In this review, we focus on the molecular pathomechanisms of impaired endothelium-dependent and flow-induced dysregulation of coronary vasomotor tone in cardiometabolic disorders such as obesity, diabetes mellitus or hyperhomocysteinemia based on animal experiments and human studies. We also briefly summarize the relationship among key signaling mechanisms that contribute to the development of coronary dysfunctions in these disorders, which may help develop new targets for efficient cardiometabolic prevention and treatments.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalInternal and Emergency Medicine
Volume8
Issue numberSUPPL. 1
DOIs
StatePublished - Mar 15 2013

Fingerprint

Hyperhomocysteinemia
Microcirculation
Endothelium
Diabetes Mellitus
Obesity
Mortality
Health

Keywords

  • Coronary circulation
  • Endothelial function
  • Hyperhomocysteinemia
  • Obesity
  • Type 2 diabetes mellitus
  • Wall shear stress

ASJC Scopus subject areas

  • Emergency Medicine
  • Internal Medicine

Cite this

Endothelial regulation of coronary microcirculation in health and cardiometabolic diseases. / Koller, Akos; Balasko, Marta; Bagi, Zsolt.

In: Internal and Emergency Medicine, Vol. 8, No. SUPPL. 1, 15.03.2013, p. 51-54.

Research output: Contribution to journalReview article

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