Endothelial regulation of coronary microcirculation in health and cardiometabolic diseases

Akos Koller, Marta Balasko, Zsolt Bagi

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Cardiometabolic disorders have been shown to impair coronary microvascular functions leading to diminished cardiac performance and increased mortality. In this review, we focus on the molecular pathomechanisms of impaired endothelium-dependent and flow-induced dysregulation of coronary vasomotor tone in cardiometabolic disorders such as obesity, diabetes mellitus or hyperhomocysteinemia based on animal experiments and human studies. We also briefly summarize the relationship among key signaling mechanisms that contribute to the development of coronary dysfunctions in these disorders, which may help develop new targets for efficient cardiometabolic prevention and treatments.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalInternal and Emergency Medicine
Volume8
Issue numberSUPPL. 1
DOIs
StatePublished - Mar 15 2013

Keywords

  • Coronary circulation
  • Endothelial function
  • Hyperhomocysteinemia
  • Obesity
  • Type 2 diabetes mellitus
  • Wall shear stress

ASJC Scopus subject areas

  • Internal Medicine
  • Emergency Medicine

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