Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway

Myrian R. Rodríguez, María E. Sabbatini, Gisela Santella, Paula Dabas, Alberto Villagra, Marcelo S. Vatta, Liliana G. Bianciotti

Research output: Contribution to journalArticle

4 Scopus citations


We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decreased bile flow and bile acid output. ET-3 effects were dependent on brain nitric oxide and independent of the autonomic nervous system or hemodynamic variations. A selective ETB antagonist abolished the cholestatic effect, whereas the choleretic effect was totally inhibited by either ET A or ETB selective blockade. These results show that ET-3 applied to the brain modified through a nitric oxide pathway distinct bile flow fractions depending on the administered dose and give further insights into the complexity of brain-liver interaction.

Original languageEnglish (US)
Pages (from-to)1219-1227
Number of pages9
Issue number7
StatePublished - Jul 1 2005



  • Bile flow
  • ET receptors
  • ET receptors
  • ET-3
  • Nitric oxide

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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