Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway

Myrian R. Rodríguez, Maria Eugenia Sabbatini, Gisela Santella, Paula Dabas, Alberto Villagra, Marcelo S. Vatta, Liliana G. Bianciotti

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decreased bile flow and bile acid output. ET-3 effects were dependent on brain nitric oxide and independent of the autonomic nervous system or hemodynamic variations. A selective ETB antagonist abolished the cholestatic effect, whereas the choleretic effect was totally inhibited by either ET A or ETB selective blockade. These results show that ET-3 applied to the brain modified through a nitric oxide pathway distinct bile flow fractions depending on the administered dose and give further insights into the complexity of brain-liver interaction.

Original languageEnglish (US)
Pages (from-to)1219-1227
Number of pages9
JournalPeptides
Volume26
Issue number7
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

Fingerprint

Endothelin-3
Cholagogues and Choleretics
Bile
Brain
Nitric Oxide
Endothelins
Hemodynamics
Neurology
Bicarbonates
Bile Acids and Salts
Liver
Rats
Autonomic Nervous System
Injections

Keywords

  • Bile flow
  • ET receptors
  • ET receptors
  • ET-3
  • Nitric oxide

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway. / Rodríguez, Myrian R.; Sabbatini, Maria Eugenia; Santella, Gisela; Dabas, Paula; Villagra, Alberto; Vatta, Marcelo S.; Bianciotti, Liliana G.

In: Peptides, Vol. 26, No. 7, 01.07.2005, p. 1219-1227.

Research output: Contribution to journalArticle

Rodríguez, Myrian R. ; Sabbatini, Maria Eugenia ; Santella, Gisela ; Dabas, Paula ; Villagra, Alberto ; Vatta, Marcelo S. ; Bianciotti, Liliana G. / Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway. In: Peptides. 2005 ; Vol. 26, No. 7. pp. 1219-1227.
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