Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway

Myrian R. Rodríguez; María E. Sabbatini; Gisela Santella; Paula Dabas; Alberto Villagra; Marcelo S. Vatta; Liliana G. Bianciotti

doi:10.1016/j.peptides.2005.02.003

Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway

Myrian R. Rodríguez, María E. Sabbatini, Gisela Santella, Paula Dabas, Alberto Villagra, Marcelo S. Vatta, Liliana G. Bianciotti

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decreased bile flow and bile acid output. ET-3 effects were dependent on brain nitric oxide and independent of the autonomic nervous system or hemodynamic variations. A selective ET_B antagonist abolished the cholestatic effect, whereas the choleretic effect was totally inhibited by either ET _A or ET_B selective blockade. These results show that ET-3 applied to the brain modified through a nitric oxide pathway distinct bile flow fractions depending on the administered dose and give further insights into the complexity of brain-liver interaction.

Original language	English (US)
Pages (from-to)	1219-1227
Number of pages	9
Journal	Peptides
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.peptides.2005.02.003
State	Published - Jul 2005
Externally published	Yes

Keywords

Bile flow
ET receptors
ET receptors
ET-3
Nitric oxide

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/j.peptides.2005.02.003

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title = "Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway",

abstract = "We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decreased bile flow and bile acid output. ET-3 effects were dependent on brain nitric oxide and independent of the autonomic nervous system or hemodynamic variations. A selective ETB antagonist abolished the cholestatic effect, whereas the choleretic effect was totally inhibited by either ET A or ETB selective blockade. These results show that ET-3 applied to the brain modified through a nitric oxide pathway distinct bile flow fractions depending on the administered dose and give further insights into the complexity of brain-liver interaction.",

keywords = "Bile flow, ET receptors, ET receptors, ET-3, Nitric oxide",

author = "Rodr{\'i}guez, {Myrian R.} and Sabbatini, {Mar{\'i}a E.} and Gisela Santella and Paula Dabas and Alberto Villagra and Vatta, {Marcelo S.} and Bianciotti, {Liliana G.}",

note = "Funding Information: This work was supported by grants from the University of Buenos Aires (UBACYT B420 and UBACYT B079).",

year = "2005",

month = jul,

doi = "10.1016/j.peptides.2005.02.003",

language = "English (US)",

volume = "26",

pages = "1219--1227",

journal = "Peptides",

issn = "0196-9781",

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T1 - Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway

AU - Rodríguez, Myrian R.

AU - Sabbatini, María E.

AU - Santella, Gisela

AU - Dabas, Paula

AU - Villagra, Alberto

AU - Vatta, Marcelo S.

AU - Bianciotti, Liliana G.

N1 - Funding Information: This work was supported by grants from the University of Buenos Aires (UBACYT B420 and UBACYT B079).

PY - 2005/7

Y1 - 2005/7

N2 - We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decreased bile flow and bile acid output. ET-3 effects were dependent on brain nitric oxide and independent of the autonomic nervous system or hemodynamic variations. A selective ETB antagonist abolished the cholestatic effect, whereas the choleretic effect was totally inhibited by either ET A or ETB selective blockade. These results show that ET-3 applied to the brain modified through a nitric oxide pathway distinct bile flow fractions depending on the administered dose and give further insights into the complexity of brain-liver interaction.

AB - We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decreased bile flow and bile acid output. ET-3 effects were dependent on brain nitric oxide and independent of the autonomic nervous system or hemodynamic variations. A selective ETB antagonist abolished the cholestatic effect, whereas the choleretic effect was totally inhibited by either ET A or ETB selective blockade. These results show that ET-3 applied to the brain modified through a nitric oxide pathway distinct bile flow fractions depending on the administered dose and give further insights into the complexity of brain-liver interaction.

KW - Bile flow

KW - ET receptors

KW - ET-3

KW - Nitric oxide

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JO - Peptides

JF - Peptides

IS - 7

ER -

Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway

Abstract

Keywords

ASJC Scopus subject areas

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