Energetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connections

Katherine M. Nautiyal, Megan Dailey, Nilton Brito, Marcia N.D.A. Brito, Ruth B. Harris, Timothy J. Bartness, Harvey J. Grill

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Hypothalamic neurons are regarded as essential for integrating thermal afferent information from skin and core and issuing commands to autonomic and behavioral effectors that maintain core temperature (Tc) during cold exposure and for the control of energy expenditure more generally. Caudal brain stem neurons are necessary elements of the hypothalamic effector pathway and also are directly driven by skin and brain cooling. To assess whether caudal brain stem processing of thermal afferent signals is sufficient to drive endemic effectors for thermogenesis, heart rate (HR), Tc, and activity responses of chronic decerebrate (CD) and control rats adapted to 23°C were compared during cold exposure (4, 8, or 12°C) for 6 h. Other CDs and controls were exposed to 4 or 23°C for 2 h, and tissues were processed for norepinephrine turnover (NETO), a neurochemical measure of sympathetic drive. Controls maintained Tc for all temperatures. CDs maintained T c for the 8 and 12°C exposures, but Tc declined 2°C during the 4°C exposure. Cold exposure elevated HR in CDs and controls alike. Tachycardia magnitude correlated with decreases in environmental temperature for controls, but not CDs. Cold increased NETO in brown adipose tissue, heart, and some white adipose tissue pads in CDs and controls compared with their respective room temperature controls. These data demonstrate that, in neural isolation from the hypothalamus, cold exposure drives caudal brain stem neuronal activity and engages local effectors that trigger sympathetic energetic and cardiac responses that are comparable in many, but not in all, respects to those seen in neurologically intact rats.

Original languageEnglish (US)
Pages (from-to)R789-R798
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume295
Issue number3
DOIs
StatePublished - Sep 1 2008

Fingerprint

Prosencephalon
Brain Stem
Temperature
Norepinephrine
Hot Temperature
Heart Rate
Neurons
White Adipose Tissue
Skin
Brown Adipose Tissue
Thermogenesis
Tachycardia
Energy Metabolism
Hypothalamus
Brain

Keywords

  • Anterior hypothalamus
  • Body temperature
  • Brown adipose tissue
  • Energy balance
  • Heart rate
  • Norepinephrine turnover
  • Sympathetic drive
  • Thermoregulation
  • White adipose tissue

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Energetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connections. / Nautiyal, Katherine M.; Dailey, Megan; Brito, Nilton; Brito, Marcia N.D.A.; Harris, Ruth B.; Bartness, Timothy J.; Grill, Harvey J.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 295, No. 3, 01.09.2008, p. R789-R798.

Research output: Contribution to journalArticle

Nautiyal, Katherine M. ; Dailey, Megan ; Brito, Nilton ; Brito, Marcia N.D.A. ; Harris, Ruth B. ; Bartness, Timothy J. ; Grill, Harvey J. / Energetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connections. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2008 ; Vol. 295, No. 3. pp. R789-R798.
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