Abstract
CD4+ T cells play an important role in regulating the immune response; their contribution to virus clearance is variable. Mice that lack CD4+ T cells (CD4(-/-) mice) and are therefore unable to produce neutralizing antibodies cleared viscero-lymphotropic lymphocytic choriomeningitis virus (LCMV) strain WE when infected intravenously with a low dose (2 x 102 PFU) because of an effective CD8+ cytotoxic T-cell (CTL) response. In contrast, infection with a high dose (2 x 106 PFU) of LCMV strain WE led to expansion of antiviral CTL, which disappeared in CD4(-/-) mice; in contrast, CD4+ T- cell competent mice developed antiviral memory CTL. This exhaustion of specific CTL caused viral persistence in CD4(-/-) mice, whereas CD4+ T- cell-competent mice eliminated the virus. After infection of CD4(-/-) mice with the faster-replicating LCMV strain DOCILE, abrogation of CTL response and establishment of viral persistence developed after infection with a low dose (5 x 102 PFU), i.e., an about 100-fold lower dose than in CD4+- competent control mice. These results show that absence of T help enhances establishment of an LCMV carrier state in selected situations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4700-4704 |
| Number of pages | 5 |
| Journal | Journal of Virology |
| Volume | 68 |
| Issue number | 7 |
| State | Published - Jan 1 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Virology
Cite this
Enhanced establishment of a virus carrier state in adult CD4+ T-cell- deficient mice. / Battegay, M.; Moskofidis, Dimitrios; Rahemtulla, A.; Hengartner, H.; Mak, T. W.; Zinkernagel, R. M.
In: Journal of Virology, Vol. 68, No. 7, 01.01.1994, p. 4700-4704.Research output: Contribution to journal › Comment/debate
}
TY - JOUR
T1 - Enhanced establishment of a virus carrier state in adult CD4+ T-cell- deficient mice
AU - Battegay, M.
AU - Moskofidis, Dimitrios
AU - Rahemtulla, A.
AU - Hengartner, H.
AU - Mak, T. W.
AU - Zinkernagel, R. M.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - CD4+ T cells play an important role in regulating the immune response; their contribution to virus clearance is variable. Mice that lack CD4+ T cells (CD4(-/-) mice) and are therefore unable to produce neutralizing antibodies cleared viscero-lymphotropic lymphocytic choriomeningitis virus (LCMV) strain WE when infected intravenously with a low dose (2 x 102 PFU) because of an effective CD8+ cytotoxic T-cell (CTL) response. In contrast, infection with a high dose (2 x 106 PFU) of LCMV strain WE led to expansion of antiviral CTL, which disappeared in CD4(-/-) mice; in contrast, CD4+ T- cell competent mice developed antiviral memory CTL. This exhaustion of specific CTL caused viral persistence in CD4(-/-) mice, whereas CD4+ T- cell-competent mice eliminated the virus. After infection of CD4(-/-) mice with the faster-replicating LCMV strain DOCILE, abrogation of CTL response and establishment of viral persistence developed after infection with a low dose (5 x 102 PFU), i.e., an about 100-fold lower dose than in CD4+- competent control mice. These results show that absence of T help enhances establishment of an LCMV carrier state in selected situations.
AB - CD4+ T cells play an important role in regulating the immune response; their contribution to virus clearance is variable. Mice that lack CD4+ T cells (CD4(-/-) mice) and are therefore unable to produce neutralizing antibodies cleared viscero-lymphotropic lymphocytic choriomeningitis virus (LCMV) strain WE when infected intravenously with a low dose (2 x 102 PFU) because of an effective CD8+ cytotoxic T-cell (CTL) response. In contrast, infection with a high dose (2 x 106 PFU) of LCMV strain WE led to expansion of antiviral CTL, which disappeared in CD4(-/-) mice; in contrast, CD4+ T- cell competent mice developed antiviral memory CTL. This exhaustion of specific CTL caused viral persistence in CD4(-/-) mice, whereas CD4+ T- cell-competent mice eliminated the virus. After infection of CD4(-/-) mice with the faster-replicating LCMV strain DOCILE, abrogation of CTL response and establishment of viral persistence developed after infection with a low dose (5 x 102 PFU), i.e., an about 100-fold lower dose than in CD4+- competent control mice. These results show that absence of T help enhances establishment of an LCMV carrier state in selected situations.
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M3 - Comment/debate
VL - 68
SP - 4700
EP - 4704
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 7
ER -