Enhanced establishment of a virus carrier state in adult CD4+ T-cell- deficient mice

M. Battegay, D. Moskophidis, A. Rahemtulla, H. Hengartner, T. W. Mak, R. M. Zinkernagel

Research output: Contribution to journalComment/debate

256 Citations (Scopus)

Abstract

CD4+ T cells play an important role in regulating the immune response; their contribution to virus clearance is variable. Mice that lack CD4+ T cells (CD4(-/-) mice) and are therefore unable to produce neutralizing antibodies cleared viscero-lymphotropic lymphocytic choriomeningitis virus (LCMV) strain WE when infected intravenously with a low dose (2 x 102 PFU) because of an effective CD8+ cytotoxic T-cell (CTL) response. In contrast, infection with a high dose (2 x 106 PFU) of LCMV strain WE led to expansion of antiviral CTL, which disappeared in CD4(-/-) mice; in contrast, CD4+ T- cell competent mice developed antiviral memory CTL. This exhaustion of specific CTL caused viral persistence in CD4(-/-) mice, whereas CD4+ T- cell-competent mice eliminated the virus. After infection of CD4(-/-) mice with the faster-replicating LCMV strain DOCILE, abrogation of CTL response and establishment of viral persistence developed after infection with a low dose (5 x 102 PFU), i.e., an about 100-fold lower dose than in CD4+- competent control mice. These results show that absence of T help enhances establishment of an LCMV carrier state in selected situations.

Original languageEnglish (US)
Pages (from-to)4700-4704
Number of pages5
JournalJournal of Virology
Volume68
Issue number7
StatePublished - Jan 1 1994

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carrier state
Carrier State
T-lymphocytes
Viruses
Lymphocytic choriomeningitis virus
T-Lymphocytes
viruses
mice
dosage
Antiviral Agents
Infection
infection
Neutralizing Antibodies
neutralizing antibodies
immune response

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Battegay, M., Moskophidis, D., Rahemtulla, A., Hengartner, H., Mak, T. W., & Zinkernagel, R. M. (1994). Enhanced establishment of a virus carrier state in adult CD4+ T-cell- deficient mice. Journal of Virology, 68(7), 4700-4704.

Enhanced establishment of a virus carrier state in adult CD4+ T-cell- deficient mice. / Battegay, M.; Moskophidis, D.; Rahemtulla, A.; Hengartner, H.; Mak, T. W.; Zinkernagel, R. M.

In: Journal of Virology, Vol. 68, No. 7, 01.01.1994, p. 4700-4704.

Research output: Contribution to journalComment/debate

Battegay, M, Moskophidis, D, Rahemtulla, A, Hengartner, H, Mak, TW & Zinkernagel, RM 1994, 'Enhanced establishment of a virus carrier state in adult CD4+ T-cell- deficient mice', Journal of Virology, vol. 68, no. 7, pp. 4700-4704.
Battegay M, Moskophidis D, Rahemtulla A, Hengartner H, Mak TW, Zinkernagel RM. Enhanced establishment of a virus carrier state in adult CD4+ T-cell- deficient mice. Journal of Virology. 1994 Jan 1;68(7):4700-4704.
Battegay, M. ; Moskophidis, D. ; Rahemtulla, A. ; Hengartner, H. ; Mak, T. W. ; Zinkernagel, R. M. / Enhanced establishment of a virus carrier state in adult CD4+ T-cell- deficient mice. In: Journal of Virology. 1994 ; Vol. 68, No. 7. pp. 4700-4704.
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