Enhanced parenchymal arteriole tone and astrocyte signaling protect neurovascular coupling mediated parenchymal arteriole vasodilation in the spontaneously hypertensive rat

Jennifer A. Iddings, Ki Jung Kim, Yiqiang Zhou, Haruki Higashimori, Jessica Andrea Filosa

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Functional hyperemia is the regional increase in cerebral blood flow upon increases in neuronal activity which ensures that the metabolic demands of the neurons are met. Hypertension is known to impair the hyperemic response; however, the neurovascular coupling mechanisms by which this cerebrovascular dysfunction occurs have yet to be fully elucidated. To determine whether altered cortical parenchymal arteriole function or astrocyte signaling contribute to blunted neurovascular coupling in hypertension, we measured parenchymal arteriole reactivity and vascular smooth muscle cell Ca 2+ dynamics in cortical brain slices from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. We found that vasoconstriction in response to the thromboxane A 2 receptor agonist U46619 and basal vascular smooth muscle cell Ca 2+ oscillation frequency were significantly increased in parenchymal arterioles from SHR. In perfused and pressurized parenchymal arterioles, myogenic tone was significantly increased in SHR. Although K + -induced parenchymal arteriole dilations were similar in WKY and SHR, metabotropic glutamate receptor activation-induced parenchymal arteriole dilations were enhanced in SHR. Further, neuronal stimulation-evoked parenchymal arteriole dilations were similar in SHR and WKY. Our data indicate that neurovascular coupling is not impaired in SHR, at least at the level of the parenchymal arterioles.

Original languageEnglish (US)
Pages (from-to)1127-1136
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Volume35
Issue number7
DOIs
StatePublished - Jan 1 2015

Fingerprint

Arterioles
Inbred SHR Rats
Vasodilation
Astrocytes
Dilatation
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cerebrovascular Circulation
Hypertension
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Metabotropic Glutamate Receptors
Neurovascular Coupling
Thromboxanes
Hyperemia
Vasoconstriction
varespladib methyl
Neurons
Brain

Keywords

  • astrocytes
  • brain slice
  • cerebral blood flow
  • hypertension
  • neurovascular coupling
  • parenchymal arterioles

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Enhanced parenchymal arteriole tone and astrocyte signaling protect neurovascular coupling mediated parenchymal arteriole vasodilation in the spontaneously hypertensive rat. / Iddings, Jennifer A.; Kim, Ki Jung; Zhou, Yiqiang; Higashimori, Haruki; Filosa, Jessica Andrea.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 35, No. 7, 01.01.2015, p. 1127-1136.

Research output: Contribution to journalArticle

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