Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8

Tsugiya Murayama; Kouji Kuno; Fumiko Jisaki; Masatsugu Obuchi; Daitoku Sakamuro; Toru Furukawa; Naofumi Mukaida; Kouji Matsushima

doi:10.1128/jvi.68.11.7582-7585.1994

Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8

Tsugiya Murayama, Kouji Kuno, Fumiko Jisaki, Masatsugu Obuchi, Daitoku Sakamuro, Toru Furukawa, Naofumi Mukaida, Kouji Matsushima

Research output: Contribution to journal › Comment/debate › peer-review

62 Scopus citations

Abstract

We examined the effects of interleukin-8 (IL-8) on cytomegalovirus (CMV) replication in human fibroblasts. Exposure of fibroblasts to IL-8 augmented both infectious virus production and replication of CMV, with concomitant increases in the levels of both the transcript of the CMV pp71 genome and the synthesis of the CMV late antigen. We also found that CMV selectively induced transcripts of the IL-8 type I receptor in fibroblasts. These results suggest that IL-8 also contributes to inflammatory diseases by enhancing CMV replication and that CMV regulates its production through induction of the IL-8 receptor.

Original language	English (US)
Pages (from-to)	7582-7585
Number of pages	4
Journal	Journal of Virology
Volume	68
Issue number	11
DOIs	https://doi.org/10.1128/jvi.68.11.7582-7585.1994
State	Published - Nov 1994
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/jvi.68.11.7582-7585.1994

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title = "Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8",

abstract = "We examined the effects of interleukin-8 (IL-8) on cytomegalovirus (CMV) replication in human fibroblasts. Exposure of fibroblasts to IL-8 augmented both infectious virus production and replication of CMV, with concomitant increases in the levels of both the transcript of the CMV pp71 genome and the synthesis of the CMV late antigen. We also found that CMV selectively induced transcripts of the IL-8 type I receptor in fibroblasts. These results suggest that IL-8 also contributes to inflammatory diseases by enhancing CMV replication and that CMV regulates its production through induction of the IL-8 receptor.",

author = "Tsugiya Murayama and Kouji Kuno and Fumiko Jisaki and Masatsugu Obuchi and Daitoku Sakamuro and Toru Furukawa and Naofumi Mukaida and Kouji Matsushima",

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T1 - Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8

AU - Murayama, Tsugiya

AU - Kuno, Kouji

AU - Jisaki, Fumiko

AU - Obuchi, Masatsugu

AU - Sakamuro, Daitoku

AU - Furukawa, Toru

AU - Mukaida, Naofumi

AU - Matsushima, Kouji

PY - 1994/11

Y1 - 1994/11

N2 - We examined the effects of interleukin-8 (IL-8) on cytomegalovirus (CMV) replication in human fibroblasts. Exposure of fibroblasts to IL-8 augmented both infectious virus production and replication of CMV, with concomitant increases in the levels of both the transcript of the CMV pp71 genome and the synthesis of the CMV late antigen. We also found that CMV selectively induced transcripts of the IL-8 type I receptor in fibroblasts. These results suggest that IL-8 also contributes to inflammatory diseases by enhancing CMV replication and that CMV regulates its production through induction of the IL-8 receptor.

AB - We examined the effects of interleukin-8 (IL-8) on cytomegalovirus (CMV) replication in human fibroblasts. Exposure of fibroblasts to IL-8 augmented both infectious virus production and replication of CMV, with concomitant increases in the levels of both the transcript of the CMV pp71 genome and the synthesis of the CMV late antigen. We also found that CMV selectively induced transcripts of the IL-8 type I receptor in fibroblasts. These results suggest that IL-8 also contributes to inflammatory diseases by enhancing CMV replication and that CMV regulates its production through induction of the IL-8 receptor.

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M3 - Comment/debate

C2 - 7933146

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Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8

Abstract

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