Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8

Tsugiya Murayama, Kouji Kuno, Fumiko Jisaki, Masatsugu Obuchi, Daitoku Sakamuro, Toru Furukawa, Naofumi Mukaida, Kouji Matsushima

Research output: Contribution to journalComment/debate

57 Citations (Scopus)

Abstract

We examined the effects of interleukin-8 (IL-8) on cytomegalovirus (CMV) replication in human fibroblasts. Exposure of fibroblasts to IL-8 augmented both infectious virus production and replication of CMV, with concomitant increases in the levels of both the transcript of the CMV pp71 genome and the synthesis of the CMV late antigen. We also found that CMV selectively induced transcripts of the IL-8 type I receptor in fibroblasts. These results suggest that IL-8 also contributes to inflammatory diseases by enhancing CMV replication and that CMV regulates its production through induction of the IL-8 receptor.

Original languageEnglish (US)
Pages (from-to)7582-7585
Number of pages4
JournalJournal of Virology
Volume68
Issue number11
StatePublished - Nov 1 1994

Fingerprint

Human herpesvirus 5
Cytomegalovirus
interleukin-8
Interleukin-8
fibroblasts
Fibroblasts
lungs
cell lines
Cell Line
Lung
Interleukin-8 Receptors
receptors
Virus Replication
Interleukin-1
Genome
antigens
Antigens
viruses
synthesis
genome

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Murayama, T., Kuno, K., Jisaki, F., Obuchi, M., Sakamuro, D., Furukawa, T., ... Matsushima, K. (1994). Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8. Journal of Virology, 68(11), 7582-7585.

Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8. / Murayama, Tsugiya; Kuno, Kouji; Jisaki, Fumiko; Obuchi, Masatsugu; Sakamuro, Daitoku; Furukawa, Toru; Mukaida, Naofumi; Matsushima, Kouji.

In: Journal of Virology, Vol. 68, No. 11, 01.11.1994, p. 7582-7585.

Research output: Contribution to journalComment/debate

Murayama, T, Kuno, K, Jisaki, F, Obuchi, M, Sakamuro, D, Furukawa, T, Mukaida, N & Matsushima, K 1994, 'Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8', Journal of Virology, vol. 68, no. 11, pp. 7582-7585.
Murayama T, Kuno K, Jisaki F, Obuchi M, Sakamuro D, Furukawa T et al. Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8. Journal of Virology. 1994 Nov 1;68(11):7582-7585.
Murayama, Tsugiya ; Kuno, Kouji ; Jisaki, Fumiko ; Obuchi, Masatsugu ; Sakamuro, Daitoku ; Furukawa, Toru ; Mukaida, Naofumi ; Matsushima, Kouji. / Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8. In: Journal of Virology. 1994 ; Vol. 68, No. 11. pp. 7582-7585.
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