Enhancement of radiation response of prostatic carcinoma by taxol: Therapeutic potential for late-stage malignancy

Balakrishna L Lokeshwar, S. M. Ferrell, N. L. Block

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Radiation therapy for advanced prostate cancer has dose-limiting complications and often results in limited tumor control. A combination of radiation and taxol, a potential radiation sensitizer, may enhance therapeutic efficacy at currently used individual doses. Human prostatic carcinoma lines in vitro, and Dunning rat prostatic adenocarcinoma in vivo, were treated with taxol and radiation individually, and in combination. Cytotoxicity of taxol was comparable between androgen sensitive and insensitive lines, with 50% growth inhibition at 9.6 to 12.7 nM. Combining agents increased cytotoxicity, with a dose modifying ratio of 1.8 at 0.1% survival. Flow cytometry showed an enhancement of radiation toxicity associated with taxol-induced cell cycle phase arrest at G2/M. Injection of taxol (4 mg/kg/day x 5), radiation dose fractionation (1.5 Gy/day x 5) and their combination significantly delayed delayed tumor growth. Adverse side effects were minimal. The results imply that combination of these agents may have clinical potential in prostate cancer treatment.

Original languageEnglish (US)
Pages (from-to)93-98
Number of pages6
JournalAnticancer Research
Volume15
Issue number1
StatePublished - May 16 1995
Externally publishedYes

Keywords

  • Chemotherapeutic agents
  • Prostate cancer
  • Radiation sensitization
  • Radiation therapy
  • Taxol

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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