Enhancement of the antiviral and interferon-inducing activities of poly r(A-U) by carminic acid

James M. Jamison, Daniel G. Flowers, Elizabeth Jamison, Sutisak Kitareewan, Keith Krabill, Kenneth S. Rosenthal, Chun che Tsai

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Experiments have been designed to systematically examine the effects of carminic acid (CAR) on the antiviral/interferon-inducing activity of poly r(A-U), using the human foreskin fibroblast-vesicular stomatitis virus bioassay system. Modulation of the antiviral/interferon-inducing activity of poly r(A-U) by carminic acid was examined at fixed poly r(A-U) concentrations of 0.05 mM or 0.2 mM while varying the carminic acid concentrations to produce variable CAR/ribonucleotide ratios ranging from 1:16 to 2:1. Carminic acid and poly r(A-U) were tested individually at the concentrations employed in the CAR/poly r(A-U) combinations. Neither the carminic acid alone nor poly r(A-U) alone were effective antiviral agents/interferon inducers. The antiviral/interferon-inducing activity of poly r(A-U) was potentiated twelve-fold at CAR/ribonucleotide ratios in the region of 1 6 to 1 4. These results suggest a synergism between the poly r(A-U) and the carminic acid at the concentrations employed in this study.

Original languageEnglish (US)
Pages (from-to)1477-1483
Number of pages7
JournalLife sciences
Volume42
Issue number15
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Jamison, J. M., Flowers, D. G., Jamison, E., Kitareewan, S., Krabill, K., Rosenthal, K. S., & Tsai, C. C. (1988). Enhancement of the antiviral and interferon-inducing activities of poly r(A-U) by carminic acid. Life sciences, 42(15), 1477-1483. https://doi.org/10.1016/0024-3205(88)90058-6