Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

Claire Rampon, Ya Ping Tang, Joe Goodhouse, Eiji Shimizu, Maureen Kyin, Joseph Zhuo Tsien

Research output: Contribution to journalArticle

606 Scopus citations


We produced CA1-specific NMDA receptor 1 subunit-knockout (CA1-KO) mice to determine the NMDA receptor dependence of nonspatial memory formation and of experience-induced structural plasticity in the CA1 region. CA1-KO mice were profoundly impaired in object recognition, olfactory discrimination and contextual fear memories. Surprisingly, these deficits could be rescued by enriching experience. Using stereological electron microscopy, we found that enrichment induced an increase of the synapse density in the CA1 region in knockouts as well as control littermates. Therefore, our data indicate that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes.

Original languageEnglish (US)
Pages (from-to)238-244
Number of pages7
JournalNature Neuroscience
Issue number3
StatePublished - Mar 1 2000


ASJC Scopus subject areas

  • Neuroscience(all)

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