Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

Claire Rampon; Ya Ping Tang; Joe Goodhouse; Eiji Shimizu; Maureen Kyin; Joe Z. Tsien

doi:10.1038/72945

Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

Claire Rampon, Ya Ping Tang, Joe Goodhouse, Eiji Shimizu, Maureen Kyin, Joe Z. Tsien

Research output: Contribution to journal › Article › peer-review

674 Scopus citations

Abstract

We produced CA1-specific NMDA receptor 1 subunit-knockout (CA1-KO) mice to determine the NMDA receptor dependence of nonspatial memory formation and of experience-induced structural plasticity in the CA1 region. CA1-KO mice were profoundly impaired in object recognition, olfactory discrimination and contextual fear memories. Surprisingly, these deficits could be rescued by enriching experience. Using stereological electron microscopy, we found that enrichment induced an increase of the synapse density in the CA1 region in knockouts as well as control littermates. Therefore, our data indicate that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes.

Original language	English (US)
Pages (from-to)	238-244
Number of pages	7
Journal	Nature Neuroscience
Volume	3
Issue number	3
DOIs	https://doi.org/10.1038/72945
State	Published - Mar 2000
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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title = "Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice",

abstract = "We produced CA1-specific NMDA receptor 1 subunit-knockout (CA1-KO) mice to determine the NMDA receptor dependence of nonspatial memory formation and of experience-induced structural plasticity in the CA1 region. CA1-KO mice were profoundly impaired in object recognition, olfactory discrimination and contextual fear memories. Surprisingly, these deficits could be rescued by enriching experience. Using stereological electron microscopy, we found that enrichment induced an increase of the synapse density in the CA1 region in knockouts as well as control littermates. Therefore, our data indicate that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes.",

author = "Claire Rampon and Tang, {Ya Ping} and Joe Goodhouse and Eiji Shimizu and Maureen Kyin and Tsien, {Joe Z.}",

note = "Funding Information: We thank E. Gould for help with stereology and statistics and reading the manuscript, and P. Tanapat for technical advice concerning the Golgi method. This work was supported in part by a postdoctoral fellowship from Fondation pour la Recherche Medicale to C.R. and by grants from Princeton University, Beckman Foundation and NIH to J.Z.T.",

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AU - Shimizu, Eiji

AU - Kyin, Maureen

AU - Tsien, Joe Z.

N1 - Funding Information: We thank E. Gould for help with stereology and statistics and reading the manuscript, and P. Tanapat for technical advice concerning the Golgi method. This work was supported in part by a postdoctoral fellowship from Fondation pour la Recherche Medicale to C.R. and by grants from Princeton University, Beckman Foundation and NIH to J.Z.T.

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N2 - We produced CA1-specific NMDA receptor 1 subunit-knockout (CA1-KO) mice to determine the NMDA receptor dependence of nonspatial memory formation and of experience-induced structural plasticity in the CA1 region. CA1-KO mice were profoundly impaired in object recognition, olfactory discrimination and contextual fear memories. Surprisingly, these deficits could be rescued by enriching experience. Using stereological electron microscopy, we found that enrichment induced an increase of the synapse density in the CA1 region in knockouts as well as control littermates. Therefore, our data indicate that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes.

AB - We produced CA1-specific NMDA receptor 1 subunit-knockout (CA1-KO) mice to determine the NMDA receptor dependence of nonspatial memory formation and of experience-induced structural plasticity in the CA1 region. CA1-KO mice were profoundly impaired in object recognition, olfactory discrimination and contextual fear memories. Surprisingly, these deficits could be rescued by enriching experience. Using stereological electron microscopy, we found that enrichment induced an increase of the synapse density in the CA1 region in knockouts as well as control littermates. Therefore, our data indicate that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes.

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Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

Abstract

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