Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

Claire Rampon, Ya Ping Tang, Joe Goodhouse, Eiji Shimizu, Maureen Kyin, Joseph Zhuo Tsien

Research output: Contribution to journalArticle

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Abstract

We produced CA1-specific NMDA receptor 1 subunit-knockout (CA1-KO) mice to determine the NMDA receptor dependence of nonspatial memory formation and of experience-induced structural plasticity in the CA1 region. CA1-KO mice were profoundly impaired in object recognition, olfactory discrimination and contextual fear memories. Surprisingly, these deficits could be rescued by enriching experience. Using stereological electron microscopy, we found that enrichment induced an increase of the synapse density in the CA1 region in knockouts as well as control littermates. Therefore, our data indicate that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes.

Original languageEnglish (US)
Pages (from-to)238-244
Number of pages7
JournalNature Neuroscience
Volume3
Issue number3
DOIs
StatePublished - Mar 1 2000
Externally publishedYes

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Memory Disorders
N-Methyl-D-Aspartate Receptors
Knockout Mice
Synapses
Fear
Hippocampus
Electron Microscopy
NMDA receptor A1

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. / Rampon, Claire; Tang, Ya Ping; Goodhouse, Joe; Shimizu, Eiji; Kyin, Maureen; Tsien, Joseph Zhuo.

In: Nature Neuroscience, Vol. 3, No. 3, 01.03.2000, p. 238-244.

Research output: Contribution to journalArticle

Rampon, Claire ; Tang, Ya Ping ; Goodhouse, Joe ; Shimizu, Eiji ; Kyin, Maureen ; Tsien, Joseph Zhuo. / Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. In: Nature Neuroscience. 2000 ; Vol. 3, No. 3. pp. 238-244.
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