Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum

John D. Meeker, Mary G. Rossano, Bridget Protas, Vasantha Padmanahban, Michael Peter Diamond, Elizabeth Puscheck, Douglas Daly, Nigel Paneth, Julia J. Wirth

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Objective: To explore associations between exposure to metals and male reproductive hormone levels. Design: Cross-sectional epidemiology study with adjustment for potential confounders. Setting: University Medical Center. Patient(s): Men recruited through two infertility clinics in Michigan. Intervention(s): Metal concentrations and reproductive hormone levels were measured in blood samples collected from 219 men. Main Outcome Measure(s): Serum FSH, LH, inhibin B, T, and sex hormone-binding globulin levels. Result(s): Cadmium, copper, and lead were all significantly or suggestively positively associated with T when modeled individually, findings that are consistent with limited previous human and animal studies. Conversely, molybdenum was associated with reduced T. A significant inverse trend between molybdenum and T remained when additionally considering other metals in the model, and a positive association between T and zinc was also found. Finally, in exploratory analysis there was evidence for an interaction between molybdenum and zinc, whereby high molybdenum was associated with a 37% reduction in T (relative to the population median level) among men with low zinc. Conclusion(s): Although reductions in T and reproductive toxicity after molybdenum exposure have been previously demonstrated in animal studies, more research is needed to determine whether molybdenum poses a risk to human reproductive health.

Original languageEnglish (US)
Pages (from-to)130-140
Number of pages11
JournalFertility and sterility
Volume93
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Molybdenum
Environmental Exposure
Testosterone
Metals
Hormones
Zinc
Sex Hormone-Binding Globulin
Reproductive Health
Cadmium
Infertility
Copper
Epidemiology
Cross-Sectional Studies
Outcome Assessment (Health Care)
Serum
Research
Population

Keywords

  • Biomarkers
  • endocrine
  • epidemiology
  • exposure
  • fertility
  • metals

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Environmental exposure to metals and male reproductive hormones : circulating testosterone is inversely associated with blood molybdenum. / Meeker, John D.; Rossano, Mary G.; Protas, Bridget; Padmanahban, Vasantha; Diamond, Michael Peter; Puscheck, Elizabeth; Daly, Douglas; Paneth, Nigel; Wirth, Julia J.

In: Fertility and sterility, Vol. 93, No. 1, 01.01.2010, p. 130-140.

Research output: Contribution to journalArticle

Meeker, John D. ; Rossano, Mary G. ; Protas, Bridget ; Padmanahban, Vasantha ; Diamond, Michael Peter ; Puscheck, Elizabeth ; Daly, Douglas ; Paneth, Nigel ; Wirth, Julia J. / Environmental exposure to metals and male reproductive hormones : circulating testosterone is inversely associated with blood molybdenum. In: Fertility and sterility. 2010 ; Vol. 93, No. 1. pp. 130-140.
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