TY - JOUR
T1 - Environmental risk factors for prevention and molecular intervention of cervical cancer
AU - Au, William W.
AU - Abdou-Salama, Salama
AU - Sierra-Torres, Carlos H.
AU - Al-Hendy, Ayman
N1 - Funding Information:
The study is partially supported by grants from the John Sealy Memorial Foundation to W. W. Au, NIEHS Pilot Project Grant #ES06676 to S.A.S. and NICHD Grant R01-HD 46228 to A.A.
PY - 2007/12/3
Y1 - 2007/12/3
N2 - Cervical cancer (CC) is potentially the most preventable and treatable cancer in human but it is a leading cause for cancer morbidity and mortality in women around the world. Therefore, more innovative prevention and treatment protocols need to be developed and implemented. With better understanding of the etiology of the disease, specific prevention protocols that involve life-style modifications to minimize the impact of environmental risk factors can be developed. It may be necessary to implement unique modification protocols for different countries. In addition, antiviral vaccine is a highly promising prevention approach. With respect to therapy, the development of more specific protocols that have fewer side effects is needed. With the availability of sophisticated molecular techniques, a new generation of targeted approach that has the potential to generate outstanding efficacy is being tested. Using the siRNA technology against the expression of human papillomavirus oncogenes, specific biological pathways that are essential to the growth and survival of the CC cells can be interrupted. Another promising approach is the molecular intervention of the estrogen pathway by blocking the expression of estrogen receptors. These molecular techniques may work by reactivating endogenous regulatory processes, e.g., the core apoptotic machinery, that can cause self-destruction of the CC cells, thus providing potentially effective molecular therapy. These topics are discussed in this review.
AB - Cervical cancer (CC) is potentially the most preventable and treatable cancer in human but it is a leading cause for cancer morbidity and mortality in women around the world. Therefore, more innovative prevention and treatment protocols need to be developed and implemented. With better understanding of the etiology of the disease, specific prevention protocols that involve life-style modifications to minimize the impact of environmental risk factors can be developed. It may be necessary to implement unique modification protocols for different countries. In addition, antiviral vaccine is a highly promising prevention approach. With respect to therapy, the development of more specific protocols that have fewer side effects is needed. With the availability of sophisticated molecular techniques, a new generation of targeted approach that has the potential to generate outstanding efficacy is being tested. Using the siRNA technology against the expression of human papillomavirus oncogenes, specific biological pathways that are essential to the growth and survival of the CC cells can be interrupted. Another promising approach is the molecular intervention of the estrogen pathway by blocking the expression of estrogen receptors. These molecular techniques may work by reactivating endogenous regulatory processes, e.g., the core apoptotic machinery, that can cause self-destruction of the CC cells, thus providing potentially effective molecular therapy. These topics are discussed in this review.
KW - Cancer prevention
KW - Cervical cancer
KW - Cigarette smoking
KW - Dominant negative estrogen receptor
KW - Estrogen
KW - Gene therapy
KW - HPV infection
KW - Molecular therapy
KW - SiRNA
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U2 - 10.1016/j.ijheh.2006.10.003
DO - 10.1016/j.ijheh.2006.10.003
M3 - Article
C2 - 17157560
AN - SCOPUS:36049021981
SN - 1438-4639
VL - 210
SP - 671
EP - 678
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
IS - 6
ER -